97例不育男子精浆中微量元素的研究

TRACE ELEMENTS IN THE SEMINAL PLASMA OF INFERTILE MEN

本文对97例不育男子及13例证实有生育能力男子精浆中的九种微量元素(锌、铁、锰、铜、镍、钾、纳、钙和镁)的浓度用原子吸收分光光度法进行了测定。结果表明:钾、钠和钙在不育与正常男子精浆中的水平几乎一样。不育症患者精浆中的铁、锰和铜浓度高于正常生育力男子精浆中的浓度,其中铁(P<0.05)和锰(P<0.01)的差异具有统计学意义。镍的浓度(P<0.05)显著低于正常男子。具有正常精子密度的不育患者精浆中铁(P<0.05)和锰(P<0.01)显著高于正常男子,锌和铜的浓度也高于正常男子,但无统计学意义。无精患者精浆中的镁(P<0.01)、镍(P<0.05)和铁(P<0.05)浓度明显低于正常男子。镁和镍在不育患者精浆中的浓度随精子密度降低而逐渐降低,但无统计学意义。经迴归处理实验数据,结果表明,锌—钾,锌—钙,锌—镁;钙—钾,钙—镁和镁—钾无论在正常组还是不育组均存在明显的正相关。作者认为结合反映前列腺功能的其他生化指标来测定精浆中的铁、锰、镍及镁的水平有利于对不育症的诊断。

The levels of 9 trace elements (Zn, Cu, Fe, Mn, Ni, K, Na, Ca. Mg) were measuredin the seminal plasma of 97 infertile and 13 fertile men by atomic absorption spectropho-tometer. According to the sperm density, the infertile men were divided into 4 groups. The le-vels of seminal plasma Ca. K and Na were almost the same between the infertile and thefertile men. The azoospermic men had significantly lower levels of Mg (P<0 .01) as com-pared with the fertile. It was shown that the levels of Fe and Mn were significantly higher and Ni wassignificantly lower (P<0.05) in all the infertile groups than the fertile. Although thelevels of Zn and Cu were also higher but were not statistically significant. The elevationsof Fe (P<0. 05) and Mn (P<0 .01) were significant in the group of infertile with normo-zoospermic. The depletion of Ni (P<0. 05) level was significant in the azoospermic males. The significant positive correlations were found between the levels of Zn-K, Zn-Ca.Zn-Mg: Ca-K, Ca-Mg and Mg-K in both infertile and fertile groups. The results suggest that the assessment of seminal plasma Fe, Mn Ni and Mg in com-bination with other parameters of prostatic function, may serve as a helpful informationfor the diagnosis of infertility in man. Further studies are needed to elucidate the role ofthese trace elements in the regulation of male fertility.