期刊文献+

LRRK2基因与帕金森病的研究进展

下载PDF
导出
摘要 帕金森病是一种由于多种因素共同作用导致的神经变性疾病。关于遗传因素对帕金森病的发病作用已有100多年的研究,越来越多的研究证明遗传因素在帕金森病发病中的有着重要作用。近些年发现的LRRK2基因与家族性及散发性帕金森病关系密切,已经成为研究热点。本文主要对LRRK2基因及其与帕金森病研究进展进行综述。
出处 《医学信息(中旬刊)》 2010年第9期2650-2651,共2页 Medical Information Operations Sciences Fascicule
关键词 LRRK2 基因 帕金森
  • 相关文献

参考文献5

  • 1刘鹏,秦川.LRRK2基因与帕金森病[J].中国比较医学杂志,2008,18(8):40-43. 被引量:3
  • 2Heather Melrose.Update on the functional biology of Lrrk2[J].Future Neurol,2008,3(6):669-681.
  • 3Yang L,Kubota C,O'Neill M,et al.Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones[J].Molec Reprod Dev,2005,71(4):431-438.
  • 4Zhenyu Yue.LRRK2 in Parkinson's disease:in vivo model and approaches for understanding pathogenic roles.FEBS J,2009,276(22):6445-6454.
  • 5张婷,曹立,陈生弟.LRRK2与帕金森病[J].国际神经病学神经外科学杂志,2007,34(5):467-471. 被引量:6

二级参考文献57

  • 1Paisan-Ruiz C,Jain S,Evans EW,et al.Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.Neuron,2004,44 (4):595-600.
  • 2Zimprich A,Biskup S,Leitner P,et al.Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.Neuron,2004,44 (4):601-607.
  • 3Ito G,Okai T,Fujino G,et al.GTP Binding Is Essential to the Protein Kinase Activity of LRRK2,a Causative Gene Product for Familial Parkinson's Disease.Biochemistry,2007,46(5):1380-1388.
  • 4West AB,Moore DJ,Choi C,et al.Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.Hum Mol Genet,2007,16(2):223-232.
  • 5Hatano T,Kubo S,Ima Si,et al.Leucine-rich repeat kinase 2 associates with lipid rafts.Hum Mol Genet,2007,16(6):678-690.
  • 6Tan EK,Skipper L,Tan L,et al.LRRK2 G2019 S founder haplotype in the Chinese population.Mov Disord,2007,22 (1):105-107.
  • 7Punia S,Behari M,Govindappa ST,et al.Absence/rarity of commonly reported LRRK2 mutations in Indian Parkinson's disease patients.Neurosci Lett,2006,409(2):83-88.
  • 8Fung HC,Chen CM,Hardy J,et al.A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan.BMC Neurol,2006,6(47):1-4.
  • 9Tan EK,Zhao Y,Skipper L,et al.The LRRK2 Gly2385Arg variant is associated with Parkinson's disease:genetic and functional evidence.Hum Genet,2007,120(6):857-863.
  • 10Lesage S,Leutenegger AL,Ibanez P,et al.LRRK2 haplotype analyses in European and North African families with Parkinson disease:a common founder for the G2019S mutation dating from the 13th century.Am J Hum Genet,2005,77(2):330-332.

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部