LRRK2基因与帕金森病的研究进展
摘要
帕金森病是一种由于多种因素共同作用导致的神经变性疾病。关于遗传因素对帕金森病的发病作用已有100多年的研究,越来越多的研究证明遗传因素在帕金森病发病中的有着重要作用。近些年发现的LRRK2基因与家族性及散发性帕金森病关系密切,已经成为研究热点。本文主要对LRRK2基因及其与帕金森病研究进展进行综述。
出处
《医学信息(中旬刊)》
2010年第9期2650-2651,共2页
Medical Information Operations Sciences Fascicule
参考文献5
-
1刘鹏,秦川.LRRK2基因与帕金森病[J].中国比较医学杂志,2008,18(8):40-43. 被引量:3
-
2Heather Melrose.Update on the functional biology of Lrrk2[J].Future Neurol,2008,3(6):669-681.
-
3Yang L,Kubota C,O'Neill M,et al.Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones[J].Molec Reprod Dev,2005,71(4):431-438.
-
4Zhenyu Yue.LRRK2 in Parkinson's disease:in vivo model and approaches for understanding pathogenic roles.FEBS J,2009,276(22):6445-6454.
-
5张婷,曹立,陈生弟.LRRK2与帕金森病[J].国际神经病学神经外科学杂志,2007,34(5):467-471. 被引量:6
二级参考文献57
-
1Paisan-Ruiz C,Jain S,Evans EW,et al.Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.Neuron,2004,44 (4):595-600.
-
2Zimprich A,Biskup S,Leitner P,et al.Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.Neuron,2004,44 (4):601-607.
-
3Ito G,Okai T,Fujino G,et al.GTP Binding Is Essential to the Protein Kinase Activity of LRRK2,a Causative Gene Product for Familial Parkinson's Disease.Biochemistry,2007,46(5):1380-1388.
-
4West AB,Moore DJ,Choi C,et al.Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.Hum Mol Genet,2007,16(2):223-232.
-
5Hatano T,Kubo S,Ima Si,et al.Leucine-rich repeat kinase 2 associates with lipid rafts.Hum Mol Genet,2007,16(6):678-690.
-
6Tan EK,Skipper L,Tan L,et al.LRRK2 G2019 S founder haplotype in the Chinese population.Mov Disord,2007,22 (1):105-107.
-
7Punia S,Behari M,Govindappa ST,et al.Absence/rarity of commonly reported LRRK2 mutations in Indian Parkinson's disease patients.Neurosci Lett,2006,409(2):83-88.
-
8Fung HC,Chen CM,Hardy J,et al.A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan.BMC Neurol,2006,6(47):1-4.
-
9Tan EK,Zhao Y,Skipper L,et al.The LRRK2 Gly2385Arg variant is associated with Parkinson's disease:genetic and functional evidence.Hum Genet,2007,120(6):857-863.
-
10Lesage S,Leutenegger AL,Ibanez P,et al.LRRK2 haplotype analyses in European and North African families with Parkinson disease:a common founder for the G2019S mutation dating from the 13th century.Am J Hum Genet,2005,77(2):330-332.
共引文献6
-
1孙晓如,卜莹,丁新生,汪维鹏,丁海霞,丁一冰,邓黎丽,王枫,周国华,黄乐群.应用基于适配器连接介导的等位基因特异性扩增法检测LRRK2基因的单核苷酸多态性[J].现代生物医学进展,2009,9(14):2716-2720. 被引量:2
-
2朱少平,鲍波.RNA干扰及其在帕金森病相关基因研究中的新进展[J].西南军医,2010,12(2):296-298.
-
3杜青青,沈勤.LRRK2基因突变与帕金森病[J].江苏大学学报(医学版),2010,20(5):455-458. 被引量:2
-
4杜青青,杨学超,吴娟娟,殷冬梅,蒋荣,田辰,沈勤.PD相关基因LRRK2表达调控的初探[J].南通大学学报(医学版),2011,31(6):409-413. 被引量:2
-
5张冬杰,刘娣,汪亮,何鑫淼,王文涛.民猪和大白猪背最长肌差异表达基因的筛选与注释[J].畜牧兽医学报,2013,44(2):181-187. 被引量:4
-
6郝颖楠,王萍.LRRK2基因多态性与帕金森病相关性的研究进展[J].医学综述,2016,22(4):670-674. 被引量:3
-
1黄如训,黄宗青.混合性中风致腔隙综合征(附23例分析)[J].中风与神经疾病杂志,1995,12(3):162-163. 被引量:8
-
2官俏兵,张晓玲.胰岛素抵抗在血管性痴呆患者中发病作用的探讨[J].浙江临床医学,2004,6(8):672-672.
-
3窦志兴,李浩,洪戈舒.混合性中风临床治疗分析[J].中国实用神经疾病杂志,1999,8(5):15-16.
-
4张颖冬.2006年卒中遗传学研究进展[J].中国卒中杂志,2007,2(2):136-139. 被引量:6
-
5于川,申斌,徐寅平.痰湿体质与缺血性脑血管病相关性探讨[J].光明中医,2015,30(3):455-456. 被引量:6
-
6孙艳玲,张汉臣,朱枚,王世农,王枢,刘念君.精神分裂症寄养子9例对照研究(摘要)[J].临床精神医学杂志,1992,2(4):249-249.
-
7陈继红,刘剑立,姬子卿.脑卒中多重危险因素认识新进展[J].中国临床康复,2004,8(25):5330-5331. 被引量:7
-
8李晓红,黄桂英,李作孝.神经肽Y对变态反应性脑脊髓炎豚鼠发病及Th1/Th2细胞平衡影响的研究[J].陕西医学杂志,2009,38(4):418-419.