摘要
本文随机单用结晶天花粉蛋白肌肉注射1.2~1.6mg或宫颈注射2.4mg抗10~14周妊娠各100例,肌注组有效率为99%,完全流产率85%,而宫颈注射组有效率100%,完全流产为97%,两组间差异有显著意义(P<0.05),宫颈注射组疗效较肌注组高,不单是途径不同,很可能与剂量有关,为了减轻副反应两组病例各取50例用地塞米松5mg肌肉注射,日二次,共二天。宫颈注射组体温升高比肌注组低0.5℃(P<0.005),而且没有注射局部副反应。两组加用地塞米松后体温在<37°5C者,宫颈组为58%,而肌注组为36%,加与不加地塞米松有明显差异(P<0.005)。为此结晶天花粉蛋白2.4mg宫颈注射加地塞米松抗10~14周妊娠疗效高,副反应轻,实为可取的方法。
The use of crystal trichosanthin protein intramuscular injection has been comparedin a randomized trial with the intracervical injection for the termination of pregnancyduring 10 to 14 weeks gestation. The efficiencies were 99% and 100% and the completeabortion rates were 85% and 97% for the intramuscular and intracervical injection grouprespectively (P<0.01). In addition to the different routes of administration, the variabledosage used for intramuscular injection 1.2-1.6mg and intracervical injection 2.4mgshould be taken into account. In order to reduce the side effects each group was dividedinto 2 subgroups, 50 cases Were given crystal trichosanthin protein only and 50 cases incombination with dexamethasonum 5mg intramuscularly. Those of the intracervicalinjection group had less fever than the intramuscular injection group (P<0.05). In bothgroups combined with dexamethasone, the body temperature 37~5℃ was 58% in intra-cervical group and 36% intramuscular group (P<0. 05). Intracervical injection of tricho-santhin 2.4mg combined with dexamethasonum Were an effective alternative to the intra-muscular injection of trichosanthin for termination of pregnancy in 10--14 weeks gestation.Not only is it more effective but also it reduces the general side effects and avoids theoccurrence of the local reaction.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1990年第1期34-37,共4页
Reproduction and Contraception
关键词
结晶天花粉
妊娠
肌注
宫颈注射
Crystal tricosanthin protein
Pregnancy
Intramuscular injectian
Intracervical injection