期刊文献+

老年2型糖尿病患者高密度脂蛋白亚类与氧化应激和颈动脉粥样硬化的相关性 被引量:6

Relationships of high density lipoprotein subclasses with oxidative stress and carotid atherosclerosis in elderly patients with type 2 diabetes
原文传递
导出
摘要 目的 探讨老年2型糖尿病患者血清高密度脂蛋白(HDL)亚类的分布特点及其与氧化应激和颈动脉粥样硬化的相关性.方法 老年2型糖尿病患者56例,男40例、女16例;老年健康对照者41例,男31例、女10例.分别测定血清HDL亚类、血清8-异前列腺素F2α及颈动脉超声.结果 老年2型糖尿病组HDL3(0.51±0.21)mmol/L,较健康对照组(0.59±0.15)mmol/L降低(t=1.991,P<0.05),HDL及HDL2亦较健康对照组降低,分别为(1.07±0.36)mmol/L对(1.18±0.32)mmol/L和(0.56±0.25)mmol/L对(0.64±0.33)mmol/L,但差异无统计学意义(t值分别为1.611和0.614,均为P>0.05);HDL3与HbA1c负相关(r=-0.503,P=0.005);血清8-异前列腺素F2α吸光度A值较健康对照组降低,分别为0.017±0.004和0.021±0.008(t=2.245,P<0.05);颈动脉平均内膜-中层厚度(IMT)较健康对照组升高,但差异无统计学意义;颈动脉斑块检出率63.3%,高于对照组的36.0%(x2=4.076,P<0.05).结论 老年2型糖尿病患者HDL亚类水平存在异常,小颗粒的HDL3水平下降,氧化应激增加,可能是导致其动脉粥样硬化的原因之一. Objective To explore the distribution characteristics of high density lipoprotein (HDL) subclasses in elderly patients with type 2 diabetes mellitus (T2DM), and to evaluate the relationships of them with oxidative stress and carotid atherosclerosis. Methods The serum levels of HDL subclasses and 8-iso-prostaglandin (PG) F2α were assayed, the carotid ultrasound examinations were executed in 56 elderly patients with T2DM (male: 40, female: 16) and 41 elderly healthy controls (male: 31, female: 10). Results Compared with control group, the serum level of HDL3 was significantly lower in T2DM group [(0.51±0.21) mmol/L vs. (0.59±0.15) mmol/L,t=1.991, P〈 0.05], and the serum levels of HDL and HDL2 were also decreased [(1.07±0.36)mmol/L vs. (1.18±0.32) mmol/L; (0.56±0.25) mmol/L vs. (0.64±0.33) mmol/L], but there were no statistical significances (t= 1.611 and 0.614 both P〉0.05). The HDL3 was negatively correlated with HbA1C (r=-0.503, P=0.005). The values of absorbance of serum 8-iso-PG F2αwere significantly decreased in T2DM group than in control group (0.017±0. 004 vs. 0. 021±0. 008,t=2.245, P〈0.05). The mean carotid intima-media thickness (IMT) was higher in T2DM group,but there was no statistically significance. The detection rate of carotid atherosclerotic plaques was significantly higher in T2DM group than in control group (63.3% vs. 36.0%, x2=4.076, P〈0.05). Conclusions The low level of small particles HDL3 as well as elevated oxidative stress may contribute to the development of atherosclerosis in elderly patients with T2DM.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2010年第8期625-628,共4页 Chinese Journal of Geriatrics
关键词 脂蛋白类 HDL 氧化性应激 糖尿病 2型 颈动脉疾病 Lipoproteins, HDL Oxidative stress Diabetes mellitus, type 2 Carotid artery diseases
  • 相关文献

参考文献11

二级参考文献59

  • 1徐勇霞,傅明德,徐燕华,杨鲁川.冠心病患者冠脉狭窄程度与血清HDL亚类组成的关系[J].四川大学学报(医学版),2004,35(4):500-502. 被引量:5
  • 2王先令,陆菊明,潘长玉.动态血糖监测系统的临床应用[J].军医进修学院学报,2005,26(1):63-65. 被引量:39
  • 3Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006, 295:1681-1687.
  • 4Gopaul NK, Anggard EE, Mallet AI, et al. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett, 1995, 368:225-229.
  • 5Murai Y, Hishinuma T, Suzuki N, et al. Determination of urinary 8-epi-prostaglandin F (2alpha) using liquid chromatography- tandem mass spectrometry: increased excretion in diabetics. Prostaglandins Other Lipid Media, 2000, 62 : 173-181.
  • 6McDonnell CM, Donath SM, Vidmar SI, et al. A novel approach to continuous glucose analysis utilizing glycemic variation. Diabetes Technol Ther, 2005, 7 : 253-263.
  • 7Mezzetti A, Cipollone F, Cuccurullo F, et al. Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm. Cardiovasc Res, 2000, 47:475-488.
  • 8Morrow JD. Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol, 2005, 25 : 279-286.
  • 9Davi G, Ciabattoni G, Consoli A, et al. In vivo formation of 8-iso prostaglandin F2cLand platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. Circulation, 1999, 99:224-229.
  • 10Davi G, Chiarelli F, Santilli F, et al. Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration. Circulation, 2003, 107:3199-3203.

共引文献45

同被引文献60

  • 1张红菊,王浩,郭忆,孙欣,徐楠,吴伟春.超声对颈动脉内-中膜厚度与冠心病相关性研究[J].中华医学超声杂志(电子版),2011,8(12):2502-2511. 被引量:13
  • 2李朝军,罗向红.不同性别糖尿病患者双侧颈动脉僵硬度的对照研究[J].中华医学超声杂志(电子版),2013,10(2):143-147. 被引量:7
  • 3赵志宏,隋秀芳,章生龙.彩色多普勒超声对2型糖尿病颈动脉病变的诊断价值[J].中国临床保健杂志,2013,16(6):626-627. 被引量:6
  • 4何敏,徐济良,吴锋.2型糖尿病大鼠主动脉内皮细胞氧化损伤及缬沙坦的保护作用[J].中国药理学通报,2007,23(3):354-358. 被引量:16
  • 5Kablak NA, Association Tracz W, Przewlocki of increased carotid T, et al. intima-mediathichness with the extent of coronary artery disease. Heart, 2004,90 : 1286-1290.
  • 6Irie Y, Katakami N, Kaneto H, et al. Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without of coronary artery disease. Atherosclerosis, 2012, 221: 438-444.
  • 7Steven M, Haffner MD , Leena MD, et al. Insulin- resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects: implications for preventing coronary heart disease during the prediabetic state. Circulation, 2000,101: 975-980.
  • 8Schalkwijk CG,Stehouwer CD. Vascular complications in diabetes mellitus:the role of endothelial dysfunction[J].Clinical Science(London),2005.143-159.
  • 9He Z,King GL. Microvascular complications of diabetes[J].Endocrinology and Metabolism Clinics of North America,2004.215-238.
  • 10Masumoto S,Akimoto Y,Oike H. Dietary phloridzin reduce blood glucose levels and reverses sglt1 expression in the small intestine in streptozotocin-induced diabetic mice[J].Journal of Agricultural and Food Chemistry,2009.4651-4656.

引证文献6

二级引证文献53

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部