期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

组织蛋白酶S及cystatinC与心血管疾病 被引量：1

下载PDF
导出
摘要 组织蛋白酶在细胞外基质重构中起核心作用,组织蛋白酶S及其内源性半胱氨酸蛋白酶抑制剂C参与了心血管疾病的发生、发展。本文综述了组织蛋白酶的生物学特性,以及组织蛋白酶S和半胱氨酸蛋白酶抑制剂C在动脉粥样硬化、内膜新生和介入术后再狭窄、动脉瘤及新生血管形成等方面的作用。
作者 顾菲菲 吕树铮
机构地区 首都医科大学附属北京安贞医院心内科 煤炭总医院心脏中心
出处 《心脏杂志》 CAS 2010年第5期770-773,共4页 Chinese Heart Journal
基金 北京市科技计划项目(D0906006040191)
关键词 细胞外基质 组织蛋白酶S 半胱氨酸蛋白酶抑制剂C 心血管疾病 动脉粥样硬化
分类号 Q556.3 [生物学—生物化学]
  • 相关文献

参考文献27

  • 1Lutgens SP, Cleutjens KB, Demen M J, et al. Cathepsin c vsteine proteases in cardiovascular disease[ J ]. Faeb J, 2007, 21 (12) : 3029 - 3041.
  • 2刘颖娴,李向平.组织蛋白酶K与心血管疾病[J].中国动脉硬化杂志,2008,16(1):75-77. 被引量：5
  • 3Benosson E, Nilsson J, Jovinge S. Cystatin C and eathepsins in eardiovascu{ar disease[J]. Front Biosci, 2008, 13:5780 -5786.
  • 4Cheng XW, Kuzuya M, Nakamura K, et al. Localization of cysteine prutease, cathepsin S, to the Surface of vascular smooth muscle cells by association with integrin cv33 [ J ]. Am J Pathol, 2006, 168 (2) :685 -694.
  • 5Nieeoli G, Conte M, Bona RD, et ul. Cystatin C is assiated with an increased eornnary athertsclerotie burden and a stable plaque phenotype in patients with ischemic heart disease and nomral glomerular titration rate [ J ]. Atherosclerosis, 2008, 198 ( 2 ) :373 - 380.
  • 6徐志强,王骏,王鸣和.胱抑素C与冠心病相关性的研究进展[J].心血管病学进展,2008,29(1):64-67. 被引量：36
  • 7Manetti L, Pardini E, Genovesi M, et al. Thyroid function differents affects serum cstatin C and creatinine concentrations[ J]. J Endocrinol Invest, 2005, 28 (4) :346 - 349.
  • 8Punturieri A, Filippov S, Allen E, et al. Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages[ J ]. J Exp Med, 2000, 192 (6) :789 - 799.
  • 9Lutgens E, Lutgens SP, Faler BC, et al. Disruption of the cathepsin K gene reduces atheroselerosis progression and induces plaque fibrosis but accelerates maerophage foam cell formation [ J ]. Circulatiory, 2006, 113( 1 ) :98 - 107.
  • 10Linke M, Gordon RE, Brillard M, et al. Degradation of apolipoprotein B-100 by lysosomal csteine cathepsins[ J ]. Biol Chem, 2006, 387(9) :1295 - 1303.

二级参考文献38

  • 1刘玉胜,鹿庆华,蒋卫东.组织蛋白酶与细胞外基质重塑[J].基础医学与临床,2006,26(9):1037-1040. 被引量：11
  • 2吴艳,王毅,杨刚毅.组织蛋白酶K与骨质疏松的研究进展[J].中国骨质疏松杂志,2006,12(5):522-524. 被引量：4
  • 3Lindholt JS, Erlandsen E J, Henneberg EW. Cystatin C deficiency is associated with the progression of small abdominal aortic aneurysms [ J ]. Br J Surg, 2001, 88 : 1472-1475.
  • 4Sukhova GK, Wang B, Libby P, et al. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-nun mice[ J]. Circ Res, 2005,96 : 368 -375.
  • 5Yetkin E, Acikgoz N, Sivri N, et al, Increased plasma levels of cystatin C and transforming growth factor-betal in patients with coronary artery, ectasia: can there be a potential interaction between cystatin C and transforming growth factor-betal [ J ]. Coron Artery Dis ,2007,18 ( 3 ) :211-214.
  • 6Noto D,Cefalu'AB,Barbagallo CM,et al. Cystatin C levels are decreased in acute myocardial infarction:effect of cystatin C G73A gene polymorphism on plasma levels[J]. Int J Cardiol,2005,101(2) :213-217.
  • 7Luc G, Bard JM, Lesueur C. et al. Plasma cystatin-C and development of coronary heart disease : The PRIME Study [ J ]. Atheroselerosis, 2006,85 ( 2 ) : 375- 380.
  • 8Koeni W,Twardella D, Brenner H, et al. Plasma concentrations of eystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate [ J ]. Clin Chem ,2005,51 (2) :321-327.
  • 9Shlipak MG,Fried LF,Crump C,et al. Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency [ J ]. Circulation, 2003,107:87-92.
  • 10Jemberg T, Lindahl B ,Jame S, et al. Cystatin C a novel predictor of outcome in suspected or confirmed non-ST-elevation acute coronary syndrome[ J ]. Circulation,2004,110:2342-2348.

共引文献39

同被引文献12

  • 1Clarke M, Bennett M . The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability. Am J Neph- rol,2006,26(6) :531-535.
  • 2Liu J,Sukhova GK, Sun JS, et al. Lysosomal cysteine proteases inatherosclerosis. Arterioscler Tlnomb Vase Bio1,2004,24 (8) : 1359-1366.
  • 3Samokhin AO, Lythgo PA, Gauthier JY,et al. Pharmacological in- hibition of cathepsin S decreases atherosclerotic lesions in Apoe-/- mice. J Cardiovasc Pharmacol,2010,56( 1 ) :98-105.
  • 4Walker B, Lynas JF, Meighan MA, et al. Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S. Biochem Biophys Res Commun ,2000,275 ( 2 ) :401 405.
  • 5Sasaki T, Kuzuya M, Nakamura K, et al. ATI blockade attenuates atberosclerotic plaque destabilization accompanied by the suppres- sion of cathepsin S activity in apoE-deficient mice. Atherosclerosis, 2010,210(2) :430-437.
  • 6Qin Y, Shi GP. Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases. Pharmacol Ther,2011,131 ( 3 ) :338-350.
  • 7Rodgers KJ, Watkins DJ, Miller AL, et al. Destabilizing role of cathepsin S in murine atherosclerotic plaques. Arterioscler, Thromb Vasc Biol,2006,26(4) :851-856.
  • 8Suganuma E,Babaev VR,MotimaM,et al. Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes es- tablished atherosclerotic plaques. J Am Soc Nephrol,2007,18( 8 ): 2311-2319.
  • 9Cheng XW, Kuzuya M ,Nakamura K, et al. Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3. Am J Pathol,2006, 168(2) :685694.
  • 10Mohamed SA, Misfeld M, Hanke T,et al. Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bi- cuspid aortic valve. Ann Anat,2010,192(3 ) :145-150.

引证文献1

心脏杂志
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部