叶绿酸防治肿瘤的作用及其机制研究进展

Progress in research of tumor treatment and prevention of chlorophyllin and its mechanisms

目的:总结国内外关于叶绿酸(CHL)在肿瘤防治研究中的作用及其相关机制的进展。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"CHL、肿瘤"等为关键词,检索2000-2010年的相关文献497篇。纳入标准:1)CHL的理化特点;2)CHL防治肿瘤的作用;3)CHL防治肿瘤的作用机制。根据纳入标准,符合分析的文献30篇。结果:CHL具有很强的抗诱变性和较好的抗肿瘤作用。其机制涉及抗氧化和清除自由基活性;抑制致癌物DNA加合物的形成;免疫调节的潜能等。结论:CHL在肿瘤防治中显示了良好的应用前景,值得进一步深入研究。

OBJECTIVE：To summarize the progress in the research of tumor treatment and prevention and its mechanism of chlorophyllin（CHL） home and abroad.METHOD：A total of 497 papers were searched with ＂CHL＂ and ＂tumor＂ as key words in PubMed and CNKI database froms 2000-2010,and 30 were finally analyzed according to the inclusion criteria as follows：1） The physical chemistry characteristics of CHL;2） The role of tumor treatment and prevention of CHL;3） The mechanism of tumor treatment and prevention of CHL.RESULTS：A large number of tests indicate CHL possesses strong antimutagenic and antineoplastic activities,which are possibly mediated by multiple mechanisms including the activities of antioxidation and free radical scavenging;suppressing the formation of DNA adduct from carcinogen;immunoregulatory potentiality and so on.CONCLUSION：CHL possesses a nice application prospect in tumour treatment prevention,and deserveing further study.