冠状动脉微血管异常、心肌细胞凋亡靶向下活血化瘀方剂吸收成分的间接与直接作用

Indirect and Direct Effects of Absorption Components of Composite for Activating Blood and Removing Stasis on Coronary Microvascular Dysfunction and Myocardial Cell Apoptosls

在冠状动脉微血管异常与心肌细胞凋亡的靶向下,发现:冠心Ⅱ号与其三种体内吸收成分(阿魏酸、丹参素、羟基红花黄色素A)的抗凋亡的疗效一致,且剂量-心肌血流量-心肌细胞凋亡存在一定的联系。本研究在上述对冠心Ⅱ号的工作基础上,进一步提出活血化瘀方剂存在剂量-心肌血流量相关的间接与直接作用的假说,即活血化瘀方高剂量急性口服保护心脏的作用是通过增加心肌血流量的间接途径,发挥抗心肌细胞凋亡作用。而低剂量口服不增加心肌血流量,慢性的心脏保护作用是通过直接途径,发挥抗心肌凋亡的作用。本文也论述了该假说的科学依据和意义。

It has been found that in case of targeted for coronary microvascular dysfunction and myocardial cell apoptosis,the anti-apoptosis effect of Guanxin No.2,a Chinese herbal composite for activating blood and removing stasis（ABRS）,is identical to that of its three absorption components（ferulic acid,Danshensu and hydroxylcarthamin yellow）,and there exists a dose/myocardial flow-dependent direct or indirect acting path. Based on which,a hypothesis regarding the dose/myocardial flow related direct/indirect action of Chinese ABRS composite,with the same targets as before,was put forward by the authors in this paper,that is,the myocardial protective effect of acute high dose administration of the composite is acted through indirectly path by increasing the myocardial flow（MF）;while that of chronic low dose administration is realized directly without change of MF. The evidence and significance of this hypothesis were discussed.