干姜挥发油纳米乳的制备与表征

Preparation and Characterization of Nanoemulsion from Volatile of Rhizoma Zingiberis

为提高干姜挥发油的水溶性及在制剂过程中的稳定性,尝试将干姜挥发油制备成纳米乳载药形式,并对其进行表征。本文将提取的干姜挥发油进行成分分析并测定HLB值,通过处方筛选确定乳剂配比,并对所得干姜挥发油纳米乳的类型、粒径分布、表面电位及稳定性进行表征。经实验测得干姜中含挥发油2.1%,为淡黄色或黄色液体,HLB值为8,以吐温-80和司盘-80为表面活性剂,乳剂的最佳体积配比为油∶乳化剂∶水=6∶1∶13,激光粒度仪测得平均粒径为41.4 nm,表面电位为-10.31±1.51 mv,离心稳定常数为21.83%。此方法所得干姜挥发油纳米乳稳定性好,在水中分散性能好、稳定,可有效减少挥发油的损失。

To improve the water-solubility of Volatile oil and the stability in the preparation process,Volatile oil containing drug was prepared in nanoemulsion form and characterized,the components of Volatile oil were analyzed and the HLB values were determined,the emulsion ratio was determined by prescription screening,and the nanoemulsion Volatile oil type,size distribution,surface potential and stability were characterized.The experiment measured ginger volatile oil accounted for 2.1%,was lignt yellow or yellow liquid with Tween-80 and-80 as the Span surfactants,HLB value was 8,the optimum volume ratio of emulsion was oil,emulsion agent,water=6∶1∶13,Laser particle size analyzer measured an average diameter of 41.4 nm,the surface potential was-10.31±1.51 mv,centrifugal stability constant was 21.83%.Volatile oil obtained by this method showed nanoemulsion stability,good dispersion in water,stability,which can effectively reduce the loss of volatile oil.