摘要
在由3,5-二氯-2,4,6-三氟吡啶经氨取代、羟基取代得到4-氨基-3,5-二氯-6-氟吡啶-2-酚的过程中,我们发现4-氨基-3,5-二氯-2,6-二氟吡啶和2-氨基-3,5-二氯-4,6-二氟吡啶均可以转化为4-氨基-3,5-二氯-6-氟吡啶-2-酚,且收率和产物纯度均较高,我们对机理进行探讨,提出该现象的原因是在碱性水溶液中存在2-羟基吡啶的酮-醇异构互变。
Started from 3,5-dichloro-2,4,6-trifluoropyridine,4-amino-3,5-dichloro-6-fluoropyridine-2-ol was obtained by amine substitution and hydroxy substitution.During this step,4-amino-3,5-dichloro-2,6-difluoro-pyridine and 2-amino-3,5-dichloro-4,6-difluoro-pyridine which were by-product were all transformed to 4-amino-3,5-dichloro-6-fluoropyridine-2-ol with high yield and purity.The mechanism was probed and the conclusion was made that it was due to keto-enol tautomerism of pyridine-2-ol in alkaline solution.
出处
《广州化工》
CAS
2010年第9期78-79,共2页
GuangZhou Chemical Industry
基金
湖北工业大学博士启动基金(编号BSQD0816)
