摘要
目的探讨血浆神经肽Y(NPY)在高血压、脑梗塞发病中的作用。方法测定48例高血压、57例脑梗塞患者的血浆NPY并与正常对照组比较。结果正常组NPY含量为(9008±3298)ng·L-1,高血压组NPY含量为(12207±3029)ng·L-1,脑梗塞组NPY含量为(15139±4936)ng·L-1。与正常组比较,高血压组和脑梗塞组血浆的NPY显著高于对照组(P<005),且随着年龄的增加而升高。结论NPY异常升高参与了高血压和脑梗塞的发病,同时,NPY的含量变化不仅与病理因素有关,也受机体老化因素的影响。
Objective To study the effects of
NPY on the development of hypertension and cerebral infarction. Methods In 48
hypertensives(average age 61 61±10 61 years,27 male and 19 female)and 57 cerebral
infarction patients(average age 67 59±9 90 years,26 male and 31 female),NPY
concentrations were determined by radioimmunoassay. Results The average level of
NPY was 90 08±32 97pg·ml 1 in the controls,122 07±30 29pg·ml 1 in
hypertensives,and 151 39±49 36pg·ml 1 in cerebral infarction
patients.Concentrations of NPY were significantly higher in hypertensives and cerebral
infarction patients( P <0 05)than in the controls.The changes were also correlated with
the increase in age in the hypertensive and cerebral infarction groups. Conclusions
Increased NPY plays a important role in the development of hypertension and cerebral
infarction and its level is increased with increasing age.
出处
《实用老年医学》
CAS
1999年第2期78-79,共2页
Practical Geriatrics
关键词
神经肽Y
高血压
脑梗塞
病理
Neuropeptide
Hypertension Cerebral infarction