高血压与脑梗塞者血浆神经肽Y含量及其变化

Significance and changes in plasma neuropeptide Y(NPY)in hypertensives and cerebral infarction patients

目的探讨血浆神经肽Ｙ（ＮＰＹ）在高血压、脑梗塞发病中的作用。方法测定４８例高血压、５７例脑梗塞患者的血浆ＮＰＹ并与正常对照组比较。结果正常组ＮＰＹ含量为（９００８±３２９８）ｎｇ·Ｌ－１，高血压组ＮＰＹ含量为（１２２０７±３０２９）ｎｇ·Ｌ－１，脑梗塞组ＮＰＹ含量为（１５１３９±４９３６）ｎｇ·Ｌ－１。与正常组比较，高血压组和脑梗塞组血浆的ＮＰＹ显著高于对照组（Ｐ＜００５），且随着年龄的增加而升高。结论ＮＰＹ异常升高参与了高血压和脑梗塞的发病，同时，ＮＰＹ的含量变化不仅与病理因素有关，也受机体老化因素的影响。

Objective To study the effects of NPY on the development of hypertension and cerebral infarction. Methods In 48 hypertensives(average age 61 61±10 61 years,27 male and 19 female)and 57 cerebral infarction patients(average age 67 59±9 90 years,26 male and 31 female),NPY concentrations were determined by radioimmunoassay. Results The average level of NPY was 90 08±32 97pg·ml 1 in the controls,122 07±30 29pg·ml 1 in hypertensives,and 151 39±49 36pg·ml 1 in cerebral infarction patients.Concentrations of NPY were significantly higher in hypertensives and cerebral infarction patients( P <0 05)than in the controls.The changes were also correlated with the increase in age in the hypertensive and cerebral infarction groups. Conclusions Increased NPY plays a important role in the development of hypertension and cerebral infarction and its level is increased with increasing age.