脐血干细胞移植治疗失代偿期肝硬化的临床效果研究

Umbilical Cord Blood Stem Cell Transplantation in Treatment of Decompensated Cirrhosis:A Preliminary Clinical Observation

目的探讨脐血干细胞移植治疗失代偿期肝硬化的临床效果。方法 20例肝硬化失代偿期患者,采取介入(经肝固有动脉或门静脉)和静脉输注途径移植脐血干细胞,移植术后3个月观察血清丙氨酸氨基转移酶(ALT)、总胆红素(TB)、凝血酶原时间(PT)和清蛋白(ALB)水平变化,同时观察术后临床症状的改善情况及不良反应。结果患者脐血干细胞移植术前与术后3个月ALT、TB、PT和ALB水平比较,差异均有统计学意义(P<0.05)。患者腹腔积液减少率为75%(15/20),乏力好转率为80%(16/20),肝病面容、肝掌及蜘蛛痣减轻率为70%(14/20)。患者移植术中和术后,未见明显不良反应和并发症发生。结论脐血干细胞移植治疗失代偿期肝硬化是一种较安全的治疗方法,可起到暂时性的肝脏支持作用。

Objective To explore the clinical effect of umbilical cord blood stem cell transplantation on decompensated cirrhosis.Methods Umbilical cord blood stem cells were transplanted by intervention（via proper hepatic artery or portal vein） and intravenous infusion in 20 patients with decompensated cirrhosis.Three months after transplantation,the changes of serum alanine aminotransferase（ALT）,total bilirubin（TB）,prothrombin time（PT） and albumin（ALB） were analyzed and post-operative improvement of clinical symptoms and adverse reactions observed.Results There was significant difference in levels of ALT,TB,PT,ALB between pre-and post-operations（P0.05）.The ascites reduction rate was 75%（15/20）,appetite and fatigue improvement rate was 80%（16/20）,the reduction rate of facies hepatica,liver palm and spider angioma was 70%（14/20）.No obvious adverse reactions and complications were noted during and after operation.Conclusion Umbilical cord blood stem cell transplantation,a safe treatment for decompensated cirrhosis,can play a temporary role in supporting liver.