白细胞分化抗原44变异型和基质金属蛋白酶-9在腺性膀胱炎中表达的研究

Expressions of CD44V6 and MMP-9 in Recurrent and Non-recurrent Cystitis Glandularis

目的探讨白细胞分化抗原44变异型(CD44V6)和基质金属蛋白酶-9(MMP-9)在腺性膀胱炎组织中的表达及临床意义。方法采用免疫组化法检测CD44V6和MMP-9在43例腺性膀胱炎组织中的表达情况,其中复发组13例和未复发组30例,并取14例正常膀胱黏膜作对照。结果 CD44V6和MMP-9在腺性膀胱炎中的表达明显高于正常膀胱黏膜组织,差异均有统计学意义(P<0.05)。CD44V6在腺性膀胱炎组织复发组与未复发组中的阳性率分别为92.3%和46.7%,两组比较差异有统计学意义(P<0.05);MMP-9在腺性膀胱炎组织复发组与未复发组中的阳性率分别为100.0%和53.3%,两组比较差异有统计学意义(P<0.05)。结论 CD44V6和MMP-9在腺性膀胱炎组织复发组中高表达,提示复发组腺性膀胱炎较未复发组增生活跃,有恶变倾向,疗效不佳。

Objective To compare the expressions and clinical significances of CD44V6 and MMP-9 in recurrence and non-ecurrent cystitis glandularis.Methods CD44V6 and MMP-9 expression were detected by immunohistochemistry in 43 specimens of cystitis glandularis,which included 13 recurrent cases and 30 non-recurrent cases,and in 14 specimens of normal bladder mucosa.Results The positive expression rate of CD44V6 and MMP-9 in specimens of cystitis glandularis were significantly higher than those in normal tissues（both P0.05）.The positive expression rates of CD44V6 were 92.3% and 46.7% in the specimens of recurrent and non-recurrent cystitis glandularis（P0.05）,and the positive expression rates of MMP-9 were 100% and 53.3% in the specimens of recurrent and non-recurrent cystitis glandularis（P0.05）.Conclusion Overexpressions of CD44V6 and MMP-9 in the recurrent cystitis glandularis suggest the active proliferation of potentially malignant tissues.Patients with positive expressions of both two indicators should be closely followed up.