多囊卵巢综合征患者血清可溶性细胞间黏附分子-1水平与脂代谢情况的相关性研究

Corrrelation between Serum sICAM-1 and Lipid Metabolism in Polycystic Ovary Syndrome Patients

目的探讨多囊卵巢综合征(PCOS)患者血清可溶性细胞间黏附分子-1(sICAM-1)水平与脂代谢情况的相关性,为PCOS患者心血管疾病的防治提供理论依据。方法以体质指数(BMI)≥24或腰臀比(WHR)≥0.8为肥胖标准,将96例PCOS患者分为肥胖A组和非肥胖A组、肥胖B组和非肥胖B组,测定sICAM-1、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白a(Lp-a),并将sICAM-1与所测临床指标进行相关分析。结果 (1)P-COS肥胖A组血清sICAM-1水平[(783.46±161.30)μg/L]较非肥胖A组[(621.52±193.15)μg/L]明显升高,差异有统计学意义(t=-3.648,P<0.05);PCOS肥胖B组血清sICAM-1水平[(814.55±93.21)μg/L]较非肥胖B组[(500.14±165.73)μg/L]明显升高,差异有统计学意义(t=-3.281,P<0.05)。(2)PCOS肥胖A组的TG明显高于非肥胖A组,肥胖B组的TC、LDL-C明显高于非肥胖B组,差异均有统计学意义(P<0.05)。(3)相关分析显示血清sICAM-1水平与TC、LDL-C水平呈正相关。结论 PCOS患者血清sICAM-1水平及脂代谢异常与肥胖有密切联系,PCOS患者sICAM-1水平随着LDL-C水平、TC水平增高而升高,应积极治疗和监测PCOS肥胖患者,以防止和减少其心血管疾病的发生发展。

Objective To investigate the correlation between soluble intercellular adhesion molecule-1（sICAM-1） concentration and lipid metabolism in patients with polycystic ovary syndrome（PCOS）,and to provide the basis for prevention and treatment of cardiovascular diseases in these patients.Methods Taking body mass index（BMI）≥24 or waist-to-hip ratio（WHR）≥0.8 as the criterion of adiposity,96 PCOS subjects were divided as obese group A,non-obese group A,obese group B,non-obese group B,All the subjects were given tests for the levels of sICAM-1,Triglycerides（TG）,Total Cholesterol（TC）,High Density Lipoprotein Cholesterol（HDL-C）,Low Density Lipoprotein Cholesterol（LDL-C）,Apolipoprotein（a）-1（ApoA1）,Apolipoprotein（b）（ApoB）,and Lipoprotein a（Lp-a）.The multiple linear regression analysis was done between sICAM-1 and clinical indexes above.Results（1）The sICAM-1level in the obese group A[（783.46±161.30）μg/L] was higher than that in the non-obese group A[（621.52±193.15）μg/L]（t=-3.648,P0.05）,and the sICAM-1level in the obese group B[（814.55±93.21）μg/L]was higher than that in the non-obese group B[（500.14±165.73）μg/L]（t=-3.281,P0.05）.（2）The TG level in the obese group A was higher than that in the non-obese group A（P0.05）,the TC and LDL-C levels in the obese group B were higher than those in the non-obese group B（P0.05）.（3）The correlation analysis showed that serum sICAM-1 level and TC,LDL-C levels were positively correlated.Conclusion The serum sICAM-1 level and lipid metabolic disorders are closely associated with obesity in PCOS patients,The sICAM-1 level of PCOS patients increases with increases of LDL-C and TC level.Treatment and monitoring should be actively conducted for obese PCOS patients so as to prevent and reduce the occurrence and development of cardiovascular diseases.