卡培他滨联合奥沙利铂治疗复发性大肠癌

Capecitabine combined with oxaliplatin in treatment of palindromia cancer of colon

目的探讨卡培他滨联合奥沙利铂治疗晚期结直肠癌的近期疗效及不良反应。方法对30例晚期大肠癌给予卡培他滨1 250 mg·m^-2分早晚服用,连服14 d,奥沙利铂150 mg·m^-2化疗第一天静脉注射,21 d一周期。2个周期后评价疗效,同时进行不良反应评估。结果 30例患者均予评价疗效,完全缓解0例,部分缓解15例,稳定9例,进展6例,总有效率50%,临床控制率80%,不良反应主要为手足综合症,恶心,呕吐,粒细胞减少等,多为Ⅰ～Ⅱ级。结论卡培他滨联合奥沙利铂治疗晚期大肠癌疗效好,不良反应可耐受,值得临床推广。

Aim To observe the short-term efficacy and safety of capecitabine combined with oxaliplatin in treatment of patients with ad-vanced stage colorectal cancer.Methods 30 evaluable patients with advanced stage cancer of colon received capecitabine（1 250 mg·m^-2,po bid） on days 1 to 14 and oxaliplatin（150 mg·m^-2iv gtt） on day 1.One cycle was 21 days.After every 2 cycles,therapeutic effi-cacy was evaluated.Adverse reactions were assessed during treatment.Results 30 patients were evaluable cases,0 case having com-plete remission,15 cases partial response,9 cases stable disease and 6 cases progressive disease.The total efficiency rate was 50%,and the clinical response rate was 80%.The main adverse reactions were hand-foot syndrome,nausea,vomiting,granulocytopenia and ect,most of which were at Ⅰ ～ Ⅱ degree.Conclusion Capecitabin combined with oxaliplatin in treatment of palindromia cancer of colon can achieve efficacy with tolerated adverse reactions and convenient medication.It is worthy of wider application.