紫外线照射对噻吗洛尔渗透大鼠皮肤的影响

Influence of Ultraviolet Irradiation on Timolol Permeability Through Rat Skin

目的：研究紫外线照射对药物透皮渗透的影响。方法：对大鼠皮肤进行噻吗洛尔渗透实验。结果与结论：实验结果表明，紫外线对在体大鼠皮肤的照射，可能通过影响生理功能而影响皮肤对药物的渗透性，长时间的照射对皮肤有损害作用，引起渗透性显著增加。紫外线对离体皮肤照射产生的破坏作用较弱。一种市售的防晒霜对皮肤防止紫外线具有一定的保护作用。

OBJECTIVES:To study the influence of UV irradiation on drug permeation through skin.METHODS:The in vivo or in vitro permeability of rat skin was investigated by using timolol as model drug after irradiation with UV ray for 6 to 24 h.RESULTS and CONCLUSTIONS:The results showed that UV irradiation for 24h in vivo significantly increased the TM permeation through rat skin. It suggests that exposure to UV ray might result in disorder of physiological functions of skin.The influence of in vitro irradiation on skin was not so great.UV protecting effect was observed after a commercial sunlight care cream was applied on mouse skin in vivo.