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应激对小G蛋白RhoB的诱导作用

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摘要 小G蛋白RhoB是一个早期反应基因,多种应激原如放射线、紫外线、缺氧、抗癌药(如5-氟脲嘧啶、顺铂)等均能迅速上调RhoB的mRNA和蛋白质水平和(或)激活RhoB。RhoB上调或被激活在细胞应激反应中具有重要的生物学意义,目前RhoB在应激中的作用渐受重视。本文就几种应激原对其影响作一介绍。
机构地区 解放军第
出处 《中国疗养医学》 2010年第10期915-917,共3页 Chinese Journal of Convalescent Medicine
关键词 小G蛋白 RHOB 应激
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参考文献35

  • 1王晓慧 卢建.细胞应激[A].见:金惠铭卢建殷莲华等主编.细胞分子病理生理学[C].郑州:郑州大学出版社,2002.127-138.
  • 2Goulding NJ,Ogbourn S,Pipitone N,et al.The inhibitory effect of dexamethasone on lymphocyte adhesion molecule ex-pression and intercellular aggregation is not mediated by lipocortin 1[J].Clin Exp Immunol,1999,118(3):376-383.
  • 3Yazawa H,Kato T,Nakada T,et al.Glucocorticoid hormone suppression of human neutrophil-mediated tumor cell cytosta-sis[J].Int J Cancer,1999,81(1):74-80.
  • 4Lim LH,Flower RJ,Perretti M,et al.Glucocorticoid recep-tor activation reduces CD11b and CD49d levels on murine eosinophils:characterization and functional relevance[J].Am J Respir Cell Mol Biol,2000,22(6):693-701.
  • 5Mori N,Horie Y,Gerritsen ME,et al.Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds[J].Gut,1999,44(2):186-195.
  • 6Huang M,Prendergast GC.RhoB in cancer suppression[J].Histol Histopathol,2006,21(2):213-218.
  • 7Zoppi N,Ghinelli A,Gardella R,et al.Effect of dexametha-sone on the assembly of the matrix of fibronectin and on its receptors organization in Ehlers-Danlos syndrome skin fi-broblasts[J].Cell Biol Int,1998,22(7-8):499-508.
  • 8Lee MJ,Ma Y,LaChapelle L,et al.Glucocorticoid enhances transforming growth factor-beta effects on extracellular matrix protein expression in human placental mesenchymal cells[J].Biol Reprod,2004,70(5):1246-1252.
  • 9Kappert K,Schmidt G,Doerr G,et al.Angiotensin II and PDGF-BB stimulate beta(1)-integrin-mediated adhesion and spreading in human VSMCs[J].Hypertension,2000,35 (1Pt2):255-261.
  • 10Fukuda K,Xie RL,Chiu JF.Bidirectional morphological changes induced by dexamethasone in Morris hepatoma cell lines McA-RH7777 and McA-RH8994:independence of fi-bronectin and its receptor[J].Exp Cell Res,1991,195 (1):207-213.

二级参考文献15

  • 1陈玉霞,李宗斌,刁飞,王燕,卢建.地塞米松抑制人卵巢癌细胞HO-8910增殖的分子机制:RhoB信号通路的作用[J].中华医学杂志,2006,86(20):1400-1404. 被引量:13
  • 2Huang M,Prendergast G C.RhoB in cancer suppression[J].Histol Histopathol,2006,21:213-218.
  • 3DuHadaway J B,Du W,Donover S,et al.Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1[J].Oncogene,2003,22:3578-3588.
  • 4Fritz G,Kaina B.Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element[J].Nucleic Acids Res,2001,29:792-798.
  • 5Fritz G,Kaina B,Aktories K.The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments[J].J Biol Chem,1995,270:25172-25177.
  • 6Gnad R,Kaina B,Fritz G.Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress[J].Exp Cell Res,2001,264:244-249.
  • 7Westmark C J,Bartleson V B,Malter J S.RhoB mRNA is stabilized by HuR after UV light[J].Oncogene,2005,24:502-511.
  • 8Gerhard R,Tatge H,Genth H,et al.Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB[J].J Biol Chem,2005,280:1499-1505.
  • 9Liu A X,Cerniglia G J,Bernhard E J,et al.RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage[J].Proc Natl Acad Sci USA,2001,98:6192-6197.
  • 10Canguilhem B,Pradines A,Baudouin C,et al.RhoB protects human keratinocytes from UVB-incduce apoptosis through epidermal growth factor receptor signaling.[J].J Biol Chem,2005,280:43257-43263.

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