摘要
目的探讨纤维结合蛋白（ＦｉｂｒｏｎｅｃｔｉｎＦＮ）含量、表达与胃癌浸润转移的关系。方法应用琼脂糖单向免疫扩散法和免疫酶染色ＡＢＣ法检测胃癌病人血清中ＦＮ的含量及其在组织中的表达。结果肿瘤病人血清中ＦＮ含量明显低于对照组，而且胃癌转移组其血清ＦＮ含量及组织中ＦＮ表达程度与非转移组间亦有明显不同（Ｐ＜０．０１）。结论胃癌浸润转移与ＦＮ含量、表达有关，血清中ＦＮ含量及组织中ＦＮ表达程度可作为反映胃癌生物学行为的指标之一。
Objective To investigate the correlation quantitatively between expression of Fibronectin(FN)
and the infiltration and metastasis of gastric carcinoma(GC).Methods Agar single diffusion and
immunohistochemical techniques were amployed to detect the fibronectin amount in blood and
exepression in tissue of the GC patients.Results The amount FN in blood of the Gc cases was
obviously lower than the control,Fibronectin centents in blood and the expression in tissue in
gc group with metastasis were significantly different with those in the nonmetastasis group( P
<0 01).Conclusions The amount and expression FN is related to the infiltration and metastasis
of GC,and may be one of the biological behavior predictors of GC.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1999年第3期152-153,共2页
Chinese Journal of Gerontology
