间苯三酚用于先兆临产镇痛的研究

Analgesic effect of phloroglucinol in threatened labor

目的评价间苯三酚对先兆临产不规律宫缩所致疼痛的影响,寻求针对先兆临产不规律疼痛安全有效的治疗方法。方法选择正常足月妊娠先兆临产住院的初产妇76例和临产刚进入潜伏期,宫口开大<2cm的住院初产妇50例,两类产妇随机分成两组:先兆临产间苯三酚组和哌替啶组各38例,临产间苯三酚组和哌替啶组各25例。间苯三酚组给予间苯三酚80mg,静脉注射;哌替啶组给予哌替啶100mg,肌内注射。观察给药后镇痛起效时间,持续时间和镇痛效果。结果先兆临产组间苯三酚和哌替啶的镇痛效果、起效时间和持续时间相比,差异无统计学意义(P>0.05)。临产潜伏期组,哌替啶的镇痛镇静作用明显优于间苯三酚。结论间苯三酚能安全有效地缓解先兆临产产妇的不规律腹痛和紧张情绪,使其得到充分休息,从而促进产程进展。

Objective To study the effects of phloroglucinol on abnormal pain during threatened labor. Methods Seventy - six normal full - term primiparae during threatened labor and 50 normal full - term primiparae during first stage of labor , were randomized into phloroglucinol group（ group A） and dolantin group（ group B） according to the WHO pain definition ,grade management stand- ards and Numeric Rating Seale（NRS）. Group A was given 80mg phloroglueino] intravenously and group B was given 100 mg dolantin intramuscularly. Results In the threatened labor group, there was no statistically significant difference in analgesic effect, time of effect onset , and duration of analgesia between the two groups. In the first stage of labor group, dolantin was more effective than phloroglueinol. Conclusions Phloroglueinol is a safe and effective analgesic for threatened labor, it can be widely used in obstetric clinic.