胶原酶对裸鼠移植肥厚性瘢痕的治疗作用

The effect of intradermal injection of collagenase in implanted hypertrophic scar in nude mice

目的观察胶原酶对肥厚性瘢痕(HTS)胶原降解的影响,探讨它对 HTS 的治疗作用。方法建立 HTS 裸鼠移植模型,局部注射胶原酶于瘢痕组织。治疗后取材行光、电镜观察和分析。结果 HTS 组织胶原纤维被降解,真皮层变薄,瘢痕缩小,质地变软,与对照组差异十分明显。结论胶原酶的局部注射可能是治疗 HTS 的较好方法。

Objective Effects of collagen degradation in hypertrophic scar by intradermal injection of collagenase were observed.Methods Hypertrophic scar was implanted into nude mice and collagenase was injected locally.Light and electron microscopic observations were carried out.Results Collagen degradation in hypertrophic scar by intradermal injecton of collagenase was observed.The implanted scars became soft,thin and small.Conclusion These results suggested that local injection of collagenase may be a useful therapeutic tool for hypertrophic scar.