氯硝西泮治疗社交恐怖症

Clonazepam in treating social phobia

目的：观察氯硝西泮治疗社交恐怖症的疗效。方法：社交恐怖症３６例（男性１５例，女性２１例，年龄２６ａ±ｓ８ａ，病程４．０ａ±２．０ａ）采用氯硝西泮４～１０ｍｇ／ｄ，ｐｏ，疗程８ｗｋ。另外采用丙米嗪治疗同类病人３２例（男性１４例，女性１８例，年龄２５．０ａ±２．７ａ，病程３．４ａ±２．７ａ），用量１００～３００ｍｇ／ｄ，ｐｏ，疗程８ｗｋ。结果：氯硝西泮组显效率为５６％，总有效率为８１％；丙米嗪组显效率为５０％，总有效率７５％，２组疗效差异无显著意义（Ｐ＞０．０５），氯硝西泮组不良反应较丙米嗪组少。结论：氯硝西泮对社交恐怖症有肯定的治疗作用，近、远期疗效较好，且不良反应较少。

AIM: To observe the efficacy of clonazepam in treating social phobia. METHODS: Thirty_six patients (M 15, F 21; age 26 a sTBZ] 8 a; course 4.0 a2.0 a) with social phobia were given clonazepam 4_10 mg/d, po , for 8 wk. Another thrity_two patients (M 14, F 18; age 24.0 a2.7 a; course 3.4 a2.7 a) were given imipramine 100_300 mg/d, po , for 8 wk. RESULTS: The excellent response rates of clonazepam group and imipramine group were 56% and 50%, the total response rates of clonazepam group and imipramine group were 81% and 75%, respectively ( P >0.05). Adverse reactions of clonazepam group were less than imipramine group. CONCLUSION: Clonazepam in treating social phobia include short_term and long_term effects is really efficacious, adverse reactions of clonazepam is mild and rare.