摘要
目的:观察赖诺普利对原发性高血压(EH)病人胰岛素敏感性的影响。方法:将56例EH病人分成2组。赖诺普利组31例(男性16例,女性15例,年龄49a±s10a),给赖诺普利10~20mg,po,qd×4wk;氢氯噻嗪组25例(男性13例,女性12例,年龄50a±11a)给氢氯噻嗪25~50mg,po,tid×4wk。结果:赖诺普利组降压总有效率为94%与氢氯噻嗪组(92%)相仿(P>0.05)。赖诺普利组空腹血糖与胰岛素均有明显降低(P<0.01)。代表胰岛素敏感性1/(FPG×FINS)的试验显著提高的差别有非常显著的意义(P<0.01),而在氢氯噻嗪组则均无此反应。结论:赖诺普利具有提高EH病人胰岛素敏感性的作用。
AIM: To observe the effects of lisinopril in the treatment of essential hypertension (EH) with insulin resistance. METHODS: Fifty_six patients with hypertension were divided into 2 groups: lisinopril group 31 patients (M 16, F 15; age 49 a s 10 a) received lisinopril 10_20 mg, poWTBZ], qd4 wk; hydrochlorothiazide (HCT) group 25 patients (M 13, F 12; age 50 a11 a) received HCT 25_50 mg, po , tid4 wk. RESULTS: Total response rate in reduced blood pressure in lisinopril group were 94%, was similar than that HCT group (92%)( P >0.05). Serum fasting glucose concentration, and fasting serum insulin concentration was decreased and insulin sensitivity was increased in lisinopril group vs before treatment ( P <0.01), HCT group had no such responses. CONCLUSION: Lisinopril has improves the insulin resistance in EH.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第3期159-161,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
赖诺普利
高血压
胰岛素抗药性
氢氯噻嗪
治疗
lisinopril
hypertension
insulin resistance
hydrochlorothiazide
blood glucose
insulin