环丙孕酮醋酸酯合成工艺改进研究

An Investigation on Technological Improvement for Synthesis of Cycloproterone Acetate

对由１，２α次甲基６，７α环氧基１７α乙酰氧基黄体酮经１，２α次甲基６氯７羟基１７α乙酰氧基黄体酮合成环丙孕酮的工艺进行了改进，改进后的工艺具有操作简便，反应时间短，收率高（７８％以上）等优点。

An improved technology was present for the synthesis of cycloproterone acetate from 1,2methylene6,7epoxy17acetoxy progesterone by way of 1,2methylene6chloro7acetoxy progesterone. This technology has some advantages such as simple operation, short reaction time and high yields over 78%.