甲氨蝶呤不同的用药方式治疗异位妊娠不良反应的观察比较

The Adverse Reactions of Ectopic Pregnancy Treated with Methotrexate by Different Ways

目的探讨甲氨蝶呤(MTX)联合米非司酮不同用药方式在治疗非破裂型异位妊娠的不良反应及临床疗效。方法将128例异位妊娠患者随机分为两组:观察组76例患者给予MTX50～75mg单次肌内注射+米非司酮共300mg,50mg/次,口服,每隔12小时1次,连用3d。对照组52例患者给予MTX20mg静脉注射×5d+米非司酮300mg一次顿服。结果两组间疗效比较差异无统计学意义;两组患者的不良反应比较,差异具有统计学意义(P<0.05);其中以胃肠道反应和口腔溃疡明显。结论两种不同用药方式治疗非破裂型异位妊娠均安全、疗效相当;但单次肌内注射甲氨蝶呤方案的胃肠道反应及骨髓抑制、口腔炎等不良反应小。

Objective To investigate clinical efficacy and adverse reactions of methotrexate combined with mifepristone for non-ruptured ectopic pregnancy in different way.Methods 128 cases with ectopic pregnancy were randomly divided into two groups：the observation group,76 cases were treated with methotrexate 50～75 mg a single intramuscular injection plus mifepristone total of 300 mg,50 mg per injection by oral,every 12 hours.Control group,52 cases were treated with methotrexate 20 mg intravenous injection×5 days ＋ mifepristone total of 300 mg,oral.Results The curative effect between the two groups had no statistical significace;comparison of adverse reactions between the two groups,there was a significant difference（P〈0.05）.Among them,gastrointestinal reactions and oral ulcers were significant.Conclusion The two different drug treatments in the non-ruptured ectopic pregnancy are safe and effective,but the program of a single intramuscular methotrexate with little reaction in aspects of gastrointestinal reaction,bone marrow suppression,stomatitis.