摘要
目的:检测子痫前期胎盘的VEGF蛋白表达水平,探讨子痫前期的发病机制。方法:采用免疫组织化学方法结合病理图像分析技术,定量分析10例正常妊娠组、17例轻度子痫前期组和13例重度子痫前期组胎盘VEGF蛋白表达。结果:VEGF蛋白主要表达与胎盘绒毛滋养细胞的胞膜及胞浆内。与正常妊娠组比较,子痫前期组胎盘VEGF蛋白表达显著减少,轻度、重度子痫前期组比较,有显著性差异。结论:子痫前期患者胎盘滋养层细胞VEGF蛋白表达减少可能是子痫前期的发病机制之一,从而为临床治疗子痫前期提供新的方向。
Objective： To detect expression of VEGF in placenta for the mechanism of the preeclampsia placenta.Method： Immunohistochemical staining method with pathological image analysis technology were taken to detect the expression of VEGF in 10 cases of normal pregnancy group,17 patients with mild preeclampsia and 13 patients with severe preeclampsia placentas.Result： Expression of VEGF mainly lies in placental trophoblast cells＇ membrane and the cytoplasm.With the normal pregnancy,expression of VEGF in placentas decreased significantly in mild and severe preeclampsia placenta groups,There was significant difference.Conclusion： Decreasing the expression of VEGF in preeclampsia trophoblast cells is the pathogenesis of preeclampsia so as to provide a new direction in the clinical treatment of preeclampsia.
出处
《河北医学》
CAS
2010年第10期1157-1160,共4页
Hebei Medicine
关键词
血管内皮生长因子
子痫前期
胎盘
滋养层细胞
Vascular endothelial growth factor （ VEGF）
Preeclampsia
Placenta
Trophoblast cells
