结直肠癌合并2型糖尿病临床特点分析

The Clinical Features of Patients with Type 2 Diabetes and Colorectal Cancer

目的:探讨结直肠癌合并2型糖尿病患者的临床特点。方法:回顾性分析782例经手术或肠镜活检病理证实的结直肠癌患者临床资料,其中62例伴发2型糖尿病患者为观察组(结直肠癌伴糖尿病组),随机抽取60例结直肠癌无糖尿病患者作为对照组,分析结直肠癌伴发糖尿病的发病率、分期及转移情况。结果:782例结直肠癌患者合并2型糖尿病62例,患病率为7.93%,标准化患病率为3.98%,与全国糖尿病标准化患病率3.21%比较差异有显著性(P<0.05);观察组分期以中晚期为主;观察组淋巴结及其他组织器官转移率为62.9%(39/62),高于无糖尿病的结直肠癌患者(41.7%,25/60)(P<0.05)。结论:2型糖尿病增加了患结直肠癌的风险性,其分期以中晚期为主,且转移率增加。

Objective： To figure out the clinical characters of patients with type 2 diabetes and colorectal cancer.Method： The clinical data of 782 colorectal cancer（CRC） patients were divided into two groups according to whether or not got type 2 diabetes mellitus.Their clinical data were reviewed and analyzed to adjusting the proportion of type-2 diabetes mellitus（DM） among CRC patients,tumor pathological type,the rate of metastasis to lymph node or other organs.Result： The standardized prevalence of type 2 diabetes mellitus among 782 CRC patients was 3.98%,significantly greater than that of national diabetes 3.21%screening between 1995 and 1997（P〈0.05）.The most tumor by stages was late.The rate of metastasis of lymph node of other organs increased in type 2 diabetes mellitus complicated with CRC than that in without type 2 diabetes mellitus（62.9%vs 41.7%%）（P〈0.05）.Conclusion： The type 2 diabetes mellitus among CRC patients was significantly greater than that of national diabetes.The most tumor by stages is late.The rate of metastasis of lymph node of other organs increased in CRC complicated with type 2 diabetes than that in CRC patients without type 2 diabetes mellitus.