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环丙沙星在大鼠体内的生理药动学模型的血流图设计 被引量：2

Rheogram of Physiologically Based Pharmacokinetic Model of Ciprofloxacin in Rats in vivo
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摘要 【目的】建立更能准确预测环丙沙星在大鼠体内药物浓度经时变化的生理药动学模型。【方法】通过搜集环丙沙星的理化性质、药动学特点及大鼠的生理生化参数,根据生理学和解剖学知识及质能守恒定律,对模型进行了必要的前提假设。【结果】成功设计了环丙沙星在大鼠的生理药动学模型的血流图。【结论】血流图的成功设计,为环丙沙星在大鼠的生理药动学模型的建立奠定了良好的基础。 Objective The objective of the study is to develop a physiologically based pharmacokinetic model for ciprofloxacin in rats to predict drug concentration changed with time more accurately.Method Through collecting the physico chemical properties and pharmacokinetic characteristics of ciprofloxacin,and the physiological and physiochemical parameters of rats,a model was hypothesized according to physiology and anatomy and mass-energy conservation laws.Result Rheogram of physiologically based pharmacokinetic model of ciprofloxacin in rats was designed successfully.Conclusion The successful design of rheogram has laid a good foundation for establishment of the physiologically based pharmacokinetic model of ciprofloxacin in rats.
作者 罗显阳 蔡芳芹 远立国 刘雅红
机构地区 华南农业大学兽医学院 福建省动物卫生监督所
出处 《中国农业科学》 CAS CSCD 北大核心 2010年第18期3857-3861,共5页 Scientia Agricultura Sinica
基金 国家自然科学基金项目(30771629 30972219) 中国博士后科学基金(20080440762)
关键词 环丙沙星 生理药动学模型 血流图 ciprofloxacin physiologically based pharmacokinetic model rheogram
分类号 S859.7 [农业科学—临床兽医学]
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参考文献26

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共引文献14

同被引文献35

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中国农业科学
2010年 第18期

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