妇康乐胶囊对大鼠凝血功能及子宫肌瘤ERα、PR表达的影响

Effect of FuKangLe Capsule on Coagulation Function and ERα,PR Expression of Rat Uterine Leiomyoma

目的:探讨妇康乐胶囊对子宫肌瘤的防治作用及可能作用机制。方法:给大鼠注射苯甲酸雌二醇和黄体酮造模,分别给予米非司酮(MFST)、桂枝茯苓胶囊(GZFL)作对照,给予妇康乐胶囊(FKL)低、中、高剂量作治疗,分别检测相关指标:子宫卵巢系数、凝血功能、子宫ERα和PR表达。结果:FKL胶囊可抑制大鼠子宫平滑肌增生,拮抗雌、孕激素,抗血小板聚集、延长凝血酶原和凝血酶时间,能显著改善凝血。结论:FKL胶囊对子宫肌瘤具有一定的防治作用。

Objectives：To explore FuKangLe capsule on the role of preventing and treatment of Uterine Leiomyoma and its possible mechanism.Methods：Rats were injected Estradiol Benzoate and progesterone to make model of Rat Wterine Leiomyoma,were given mifepristone（MFST）and GuiZhiFuLing capsule（GZFL）as control medicine,were given FuKangLe capsule（FKL）low,medium,high dose as treatment.Related indicators were measured：uterine coefficient and ovarian coefficient,coagulation function,expression of estrogen receptor α（ER α）and progesterone receptor（PR）.Results：FKL capsule inhibits the proliferation of uterine smooth muscle,fight against estrogen and progesterone.Also it can fight against platelet aggregation,prolong prothrombin time and thrombin time,significantly improve blood clotting.Conclusions：FKL capsule plays a role in preventing and treating uterine leiomyoma.