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硝酸甘油及线粒体乙醛脱氢酶对心肌保护作用的研究进展 被引量：1

Research Progress of Nitroglycerin and Mitochondrial Acetaldehyde Dehydrogenase in Myocardial Protection
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摘要 缺血预处理是预防心脏缺血再灌注损伤有效的方法之一,近来发现:药物预处理也能够模拟缺血预处理的机制,减轻心肌缺血再灌注损伤。硝酸甘油预处理能保护心肌,减轻缺血再灌注损伤;其机制与预处理保护机制中线粒体内信号通路有关。线粒体乙醛脱氢酶是硝酸甘油的主要代谢酶,其本身活性的增高也能减轻心肌缺血再灌注损伤。 Ischemic preconditioning is one effective strategy to reduce the effects of myocardial ischemia-reperfusion injury.Experiments have demonstrated that pharmacal preconditioning can imitate the mechanism of ischemic preconditioning and therefore reduce the injury.Nitroglycerin preconditioning is one possible option.Nitroglycerin＇s mechanism is associated with intramitochondrial signaling.Mitochondrial acetaldehyde dehydrogenase is the main metabolic enzyme of nitroglycerin,which means its activation can alleviate the ischemia-reperfusion of heart.
作者 王群英 刘新伟
机构地区 重庆医科大学附属第一医院麻醉科
出处 《心血管病学进展》 CAS 2010年第5期708-711,共4页 Advances in Cardiovascular Diseases
关键词 硝酸甘油 预处理 线粒体乙醛脱氢酶 nitroglycerin ischemic preconditioning mitochondrial acetaldehyde dehydrogenase
分类号 R972.9 [医药卫生—药品] R541.4 [医药卫生—心血管疾病]
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参考文献25

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二级参考文献15

  • 1徐丹令,孙爱军,王时俊,付晗,贾剑国,王克强,邹云增,葛均波.乙醛脱氢酶2在大鼠心肌缺氧损伤中的抗凋亡作用[J].中国病理生理杂志,2006,22(4):683-686. 被引量：24
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心血管病学进展
2010年 第5期

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