摘要
目的探讨血管紧张素转化酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）多态性与中国原发性高血压（ＥＨ）人群血管并发症之间的关系。方法应用ＰＣＲ技术扩增位于ＡＣＥ基因第１６内含子的一基因片段，共检测ＥＨ患者２０４例和正常对照９６例。结果ＥＨ组ＤＤ、ＤＩ、Ｉ型基因的分布频率与对照组无显著性差异，但三期ＥＨ亚组ＤＤ型基因及Ｄ等位基因的分布频率高于正常对照组（Ｐ＜０．０１）。血浆ＡＣＥ活性与基因类型的关系为ＤＤ＞ＤＩ＞Ｉ。结论中国原发性高血压人群ＡＣＥ基因１６内含子插入／缺失多态性与其血管并发症密切相关。
Objective \ To
study the relation between insertion/deletion polymorphism of ACE gene and vascular
complicatios in essential hypertension (EH) in Chinese. \ Methed \ The fragment located at
intron 16 of ACE gene were examined by PCR.\ Results \ No significant differences among the
three genotypes(DD, DI, II) were found between EH group and control, but the frequency of DD
genotype and D allele were significantly higher among EH stage subgroup than control
(P<0.01). Serum ACE activity in three genotypes were: DD>DI>II.\ Conclusion \ Deletion
polymorphism of ACE gene is associated with vascular complication of EH in Chinese.\=
出处
《高血压杂志》
CSCD
1999年第2期128-130,共3页
Chinese Journal of Hypertension
基金
山东省自然科学基金
关键词
原发性
高血压
基因多态性
并发症
ACE
insertion/deletion polymorphism
\ ACE gene
\ hypertension
\ vascular complication
