高血压左室肥厚与血清ACE水平及动态血压的关系

Left Ventricular Hypertrophy and Serum ACE Level,Ambulatory Blood Pressure Monitoring in Hypertension

目的左室肥厚（ＬＶＨ）是心血管疾病的独立危险因子。观察高血压左室肥厚与血清ＡＣＥ水平及动态血压的关系，探讨ＬＶＨ的影响因素。方法１０４例原发性高血压患者采用超声心动图检测有无ＬＶＨ，同时作２４小时动态血压监测（ＡＢＰＭ），血清ＡＣＥ水平用人工合成的马尿酰甘氨酰甘氨酸作为底物，比色法测定。结果（１）ＡＢＰＭ显示高血压左室肥厚与左室正常两组仅夜间收缩压及夜间平均动脉压有统计学差异，余ＡＢＰＭ指标差异无显著性；（２）血清ＡＣＥ水平两组差异无显著性。结论高血压左室肥厚与２４小时动态血压间关系不十分密切，仅夜间收缩压及夜间平均动脉压与之有关，血清ＡＣＥ水平与ＬＶＨ无明显关系，可能是血清ＡＣＥ水平并不能反映组织ＡＣＥ水平所致，有待进一步研究。

Aim \ Left ventricular hypertrophy (LVH) is a major independent risk factor for morbidity and motality of cardiovascular disease. To investigate the LVH risk factors,we studied the relationship between Echocardiographic criteria and the serum angiotensin converting enzyme(ACE) concentration.\ Methods\ LVH was determined by echocardiography in 104 hypertensive subjects. All subjects were examined with ABPM. ACE was measured by colorimetery.\ Results]\ (1) The ABPM revealed that only night time SBP/MAP were different between LVH(+) and LVH(-) groups. There were no differences in other data between the two groups;(2) No significant difference of plasma ACE level between the two groups was found.\ Conclusion \ There were no significant difference in BP ambulatory monitoring data and serum ACE level,except night time SBP/MAP.