重度高血压降压治疗前后血浆神经肽Y的变化

Alteration of Plasma Neuropeptide Y in Severe Hypertension \;during Antihypertensive Treatment

目的观察重度高血压患者降压治疗前后血浆神经肽Ｙ（ＮＰＹ）浓度的变化，探讨血压变化与血浆ＮＰＹ浓度变化的关系。方法用放射免疫法测定１５例重度原发性高血压患者降压治疗前后的血浆ＮＰＹ浓度。１５例临界轻型高血压患者和１５例健康献血员分别作为高血压和正常血压对照组。结果重度高血压患者治疗前后的血浆ＮＰＹ浓度均高于正常，降压治疗后血浆ＮＰＹ浓度下降４９．８％（Ｐ＜０．００１），此时的血压水平与临界轻型高血压相近，而血浆ＮＰＹ浓度较高（Ｐ＜０．０１）。治疗前后的血浆ＮＰＹ浓度与舒张压或收缩压均无直线相关性。结论血浆ＮＰＹ的变化可能是血压急剧变化的结果，而不是其原因。

Aim \ To investigate alterations of plasma neuropeptide Y(NPY) concentration in severe hypertensive patients during antihypertensive treatment, and to verify the speculated association between blood pressure and plasma NPY concentration.\ Methods \ The plasma NPY concentrations were measured by radioimmunoassay before and after oneweek antihypertensive therapy in 15 severe hypertensive patients. 15 mild hypertensive patients and 15 healthy blood donors were taken as controls.\ Results \ The plasma NPY concentration was higher in severe hypertensives than in normal controls. After treatment, the plasma NPY concentration in severe hypertensives reduced by 49.8%, but still remained higher than either in normal controls or in mild hypertensives, though the blood pressure decreased to an acceptable level. There was no correlation either before or after treatment between SBP,DBP,and plasma NPY concentration.\ Conclusion \ Alteration of plasma NPY concentration might be the effect of rapid change in