摘要
目的观察高血压病人血清一氧化氮（ＮＯ）的水平及药物干预的影响。方法应用比色法测定了３０例正常人和６０例轻中度原发性高血压病人的血清ＮＯ水平，其中５０例高血压病人在应用卡托普利、苯那普利或硝苯地平治疗６周至８周后，复查了血清ＮＯ的浓度。结果高血压病人血清ＮＯ水平较正常对照组明显降低（Ｐ＜０．０１），Ⅱ期病人明显低于Ⅰ期病人（Ｐ＜０．０５），经卡托普利或苯那普利治疗后血清ＮＯ水平明显升高（Ｐ＜０．０５），硝苯地平治疗后无显著变化（Ｐ＞０．０５）。结论高血压病人体内ＮＯ水平显著降低，卡托普利或苯那普利治疗后ＮＯ水平明显升高。提示ＮＯ在高血压病的发生发展中有一定的作用。
Aim \ To investigate the changes of nitric oxide (NO) level in serum and
pharmaceutical interference in patients with hypertension.\ Methods \ The NO level in serum
were measured in patients with hypertension in different stages(stage:30,stage:30)and
normotensive subjects(30).\ Results \ The NO level in serum in patients of stage and stage
hypertension(57.4518.58 mol/L and 46.1317.67 mol/L)were significantly lower than that of
control group (68.5216.43 mol/L,P<0.05 and P<0.01). In patients of stage hypertension NO were
significantly lower than that of stage(P<0.05).The NO level in serum in patients with
hypertension after captopril (25 mg75 mg/d,n=21) or benazepril (5 mg20mg/d,n=17) treatment
for 6 w8 w (58.5819.72 mol/L)were significantly higher than those before treatment(48.718.16
mol/L,P<0.05). NO significant change was observed in the nifedipine group (20 mg60
mg/d,n=12;47.2418.95 mol/L,50.7618.36 mol/L,P>0.05).\ Conclusion The NO level in serum
inpatients with hypertension was lower than that of normal controls, and was significantly
increased after captopril or benazepril.
出处
《高血压杂志》
CSCD
1999年第2期144-146,共3页
Chinese Journal of Hypertension
