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高血压病患者血浆一氧化氮、血管紧张素Ⅱ的变化及意义 被引量:1

Changes of plasma nitric oxide and angiotensinⅡ in patients with essential hypertension
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摘要 目的探讨高血压病患者血浆一氧化氮(NO)、血管紧张素Ⅱ(AngⅡ)浓度的变化及其与高血压发病关系。方法用重氮法和放射免疫法分别检测50例EH患者治疗前后及36例正常对照组血浆NO、AngⅡ浓度。结果(1)EH患者血浆NO浓度较正常对照组明显降低(P<001),AngⅡ较正常对照组明显增高(P<001),经降压治疗后EH患者血浆AngⅡ浓度恢复至正常,NO浓度有明显地增高(P<001),但仍明显低于正常对照组(P<001);(2)EH患者血浆NO与AngⅡ呈负相关(γ=-086,P<001);(3)EH患者平均动脉压(MAP)与NO呈负相关,与AngⅡ呈正相关(γ=-082,F=5103,P<001)。结论NO、AngⅡ共同参与高血压的发生和发展。 Objetive To investigate the changes of plasma nitric oxide(NO) and angiotensin Ⅱ(AngⅡ) levels and their relationship to the pathogenesis of essential hypertension(EH).Methods Plasma NO and Ang Ⅱ were measured in 50 patients with EH before and after treatment and in 36 control subjects.Results NO was defermined by Griess assay while Ang Ⅱ was detected by radioimmunoassay.The results showed that the plasma NO level was reduced markedly in hypertensive patients as compared with the control subjects ( P <0 01);the plasma Ang Ⅱ level was increased significantly over the controls.After treatment,the level of Ang Ⅱ was reduced to normal level( P >0 05),the level of NO was increased significantly( P <0 01),but it was still lower than that in the controls ( P <0 01).The plasma NO had negative correlation with Ang Ⅱ in hypertensive patients ( γ =-0.86, P <0 01).Mean arterial pressure was positively corre ated with Ang Ⅱ,negatively with NO in hypertensive patients( γ =-0.82, F =51.03, P <0 01).Conclusion The results suggest that plasma NO and Ang Ⅱ are correlated with the pathogenesis and severity of EH.
出处 《武警医学》 CAS 1999年第5期258-260,共3页 Medical Journal of the Chinese People's Armed Police Force
关键词 高血压 一氧化碳 血管紧张素Ⅱ 病理 Essential hypertension Nitric oxide Angiontensin Ⅱ
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