新疆农村维吾尔族成人慢性牙周炎与慢性肾功能不全相关性的研究

Association between Chronic Periodontitis and Renal Insufficiency in Rural Adult Uygur Residents in Xinjiang

目的探讨新疆农村维吾尔族成人慢性牙周炎与慢性肾功能不全的关系。方法采用分层随机抽样方法从墨玉县364个村抽取15个村的维吾尔族成年居民1650人,进行问卷调查、相关危险因素调查、慢性肾损伤指标检测及口腔检查。依据慢性牙周炎的诊断标准,将居民分为慢性牙周炎组和非牙周炎组,其中慢性牙周炎组按病变严重程度分为:轻度、中度和重度牙周炎组。采用中国校正简化的肾病膳食改良试验(MDRD)公式计算肾小球滤过率(eGFR),当eGFR<60ml·min-1.(1.73m2)-1时诊断为慢性肾功能不全。结果在资料完整的1415人中慢性牙周炎患病率为66.0%(934/1415),慢性肾功能不全的患病率为1.3%(19/1415)。对慢性牙周炎患病有统计学意义的因素有年龄、性别、慢性肾功能不全、糖代谢异常、三酰甘油异常、总胆固醇异常、高脂血症、肥胖、高血压、代谢综合征、心肌梗死及脑卒中(P<0.05)。慢性牙周炎不同病变程度患者肾功能不全的患病率比较,差异有统计学意义(P<0.01)。慢性牙周炎严重程度与eGFR呈负相关(r=-0.236,P<0.01)。结论在慢性牙周炎人群中肾功能不全的患病率高于非牙周炎人群,慢性牙周炎的病变程度与eGFR呈负相关,随着慢性牙周炎病变程度的加重eGFR下降,但两种疾病之间相关性的本质仍需进一步明确。

Objective To explore the association between chronic periodontitis and renal insufficiency in rural adult Uygur residents in Xinjiang.Methods A total of 1 650 adult Uygur residents in the rural areas of Moyu county were randomly selected for questionnaire-based survey.In addition,after oral examinations,the subjects were divided into periodontitis group and non-periodontitis group.The periodontitis group was further divided into mild,moderate,and severe periodontitis groups.Renal insufficiency is defined as emendatory glomerular filrration rate （eGFR） less than 60 ml·min-1·（1.73 m2）-1.Results Among 1 415 patients with complete data,934 （66.0%） suffered from chronic periodontitis.Meanwhile,the prevalence of renal insufficiency was 1.3%（19/1 415）.Risk factors for chronic periodontitis included gender,age,chronic renal insufficiency,abnormal triacylglycerol,cholesterol or glycometabolism,hyperlipidemia,obesity,hypertension,metabolism syndrome,myocardial infarction,and stroke （P0.05）.The prevalence of renal insufficiency was also significantly different among mild,moderate,and severe periodontitis groups （P0.01）.The degree of periodontitis was negatively correlated with the eGFR（r=-0.236,P0.01）.Conclusion The prevalence of renal insufficiency is higher in periodontitis populations than in non-periodontitis populations.The degree of periodontitis is negatively correlated with eGFR,which may progressively decrease along with the aggregation of chronic periodontitis.However,further study is required to identify the exact relationship between these two diseases.