老年单纯收缩期高血压与部分炎症因子的相关性分析

Association between Isolated Systolic Hypertension and Serum Levels of Inflammation Factors in Elderly Patients

目的探讨老年单纯收缩期高血压与血清超敏C-反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的相关性。方法选择120例老年患者,根据血压水平分为血压正常组、单纯收缩期高血压(ISH)组、双期高血压(SDH)组,每组各40例,分别测定并比较血清hs-CRP、IL-6、TNF-α水平。结果 ISH组血清中IL-6、TNF-α水平为(0.20±0.04)μg/L和(9.98±3.20)fmol/ml,明显高于血压正常组的(0.17±0.05)μg/L、(8.03±2.84)fmol/ml,差异有统计学意义(P<0.05),与SDH组[(0.21±0.04)μg/L、(10.24±3.49)fmol/ml]比较差异无统计学意义(P>0.05)。IL-6、TNF-α水平与收缩压水平呈正相关(r值分别为0.28和0.30,P<0.05)。结论老年单纯收缩期高血压患者血清中IL-6、TNF-α水平较高,炎症反应可能参与了老年单纯收缩期高血压的发生发展。

Objective To investigate the relationship between isolated systolic hypertension（ISH） and serum levels of high-sensitivity c-reactive protein （hs-CRP）,interleukin-6 （IL-6）,tumor necrosis factor-α（TNF-α） in elderly patients.Methods Based on the blood pressure levels,120 elderly patients were divided into three groups with 40 patients in each group： normal blood pressure group,ISH group,and systolic/diastolic hypertension （SDH） group.The serum levels of hs-CRP,IL-6,and TNF-α were determined and compared among these three groups.Results The levels of IL-6 and TNF-α were significantly higher in ISH group than in control group （P0.05） and were significantly lower than in SDH group （P0.05）.The levels of IL-6 and TNF-α were positively correlated with systolic blood pressure （r=0.28,0.30,P0.05）.Conclusion The serum levels of IL-6 and TNF-α are relatively high in elderly patients with ISH.Inflammatory response may play an important role in the pathogenesis of ISH in elderly people.