0.1%他克莫司软膏治疗老年口腔扁平苔藓疗效观察

The Efficacy of Tacrolimus 0.1% Ointment in Elderly Patients with Oral Lichen Planus

目的:比较0.1%他克莫司软膏和0.025%氟轻松软膏对老年口腔扁平苔藓的疗效和安全性。方法:112例老年口腔扁平苔藓分为两组,分别给与0.1%他克莫司软膏(60例)和0.025%氟轻松软膏(52例)每日2次治疗4周,治疗结束时评价疗效和安全性。继续随访4周观察复发情况。结果:他克莫司组痊愈率33.33%,氟轻松组痊愈率15.38%,差异具有统计学意义(P<0.05);两组不良反应发生率和复发率比较具有统计学意义(P<0.05);糜烂溃疡型组的痊愈率要高于红斑萎缩型和角化过度型(P<0.05)。结论:0.1%他克莫司软膏治疗老年口腔扁平苔藓比0.025%氟轻松软膏疗效高、复发率低,但是不良反应发生率较高;0.1%他克莫司软膏治疗糜烂溃疡型老年口腔扁平苔藓可获得较高的疗效。

Objective：To compare the efficacy and the safety of tacrolimus 0.1% ointment with fluocinolone acetonide 0.025% ointment in elderly patients with oral lichen planus（OLP）.Methods：A total of 112 patients were divided into two groups randomly.60 patients were treated with tacrolimus 0.1% ointment 2 times daily,and 52 were treated with fluocinolone acetonide 0.025% ointment 2 times daily.The efficacy and the safety were graded after 4 weeks.The recurrence rate was evaluated in the following 4 weeks.Results：Of the 2 groups,there were obvious statistic differences in the cure rate and recurrence rate and side-effects rate（P0.05）.There was a higher cure rate in erosive/ulcerative OLP group than atrophic/erythematous OLP group or hyperkeratotic OLP group（P0.05）.Conclusions：Topical tacrolimus 0.1% ointment induced a better initial therapeutic response and less recurrence than fluocinolone acetonide 0.025% ointment in elderly patients with oral lichen planus.However,side-effects occurred more frequently.Topical tacrolimus 0.1% ointment was more effective for erosive/ulcerative OLP in elderly patients.