咳嗽变异性哮喘临床分析

Clinical analysis Of cough variant asthma

目的 探讨咳嗽变异性哮喘的临床特点,了解目前常用治疗方法的有效性.方法 回顾性分析本院67例咳嗽变异性哮喘患者临床表现和误诊原因.治疗方法为口服特布他林片0.065 mg/kg,3 次/d;酮替芬片2次/d,疗程4～6周.结果 本组患者在本院确诊前有42例被误诊为反复上呼吸道感染.服药2～5 d咳嗽症状消失者27例（40.3%）,6～12 d 20例（29.9%）,13～21 d 20例（29.9%）.67例患者中,有5例出现心率增快,3例出现口干,7例出现一过性手指震颤,均于停药后自行消失.结论 咳嗽变异性哮喘患者的临床表现不典型,提高对该病的认识、熟练掌握诊断标准是防止误诊和误治的关键,特布他林和酮替芬治疗咳嗽变异性哮喘效果良好.

Objective To study the clinical characteristic of cough variant asthma （CVA） and outcome of nowadays therapy. Methods Clinical characteristics of 67 patients with CVA and the possible reasons for being misdiagnosed were analyzed retrospectively, and the curative effects were observed. Results The main characteristic of CVA was chronic cough, without pulmonary sign. Before final diagnosis, 42 cases were misdiagnosed and treated as recurrent infection in up respiratory tract. Skin allergen test, bronchi dilation test and IgE examination could help make diagnosis. Terbutaline sulfate and kitotffen fumarate had profound effects in treatment of CVA. Conclusions Clinical symptom of CVA is not specific. Improving recognition of this disease and well use of diagnosis criteria are the key to avoid wrong diagnosis and treatment. Applications of Terbutaline sulfate and kitotifen fumarate have good curative effects.