不同治疗方案对甲亢近期和远期的疗效比较

The short term effect and long term effect comparison of different therapeutic schemes in the patients with hyperthyroidism

目的 探讨不同治疗方案对甲亢的近期及远期疗效.方法 选取2006年1月～2007年1月于笔者院进行治疗的60例甲亢患者为研究对象,将其随机分为A组（131I治疗组）30例和B组（抗甲状腺药物组）30例,后将两组患者的治愈率、复发率、不良反应、远期并发症发生率及血清血管紧张素Ⅰ转换酶（SACE）、一氧化氮、透明质酸（HA）及IgG、IgM、IgA、C3、C4水平等进行研究及比较.结果 经研究比较发现,A组的治愈率高于B组,且血清SACE、NO、HA、IgG、IgM、IgA、C3水平均低于B组,复发率及不良反应发生率均低于B组,但远期并发症发生率却高于B组,经比较,P均〈0.05,均有显著性差异.结论 131I治疗甲亢综合效果较好,但远期并发症发生率较高,应引起注意.

Objective To the short term effect and long term effect comparison of different therapeutic schemes in the patients with hyperthyroidism. Methods 60 cases patients with hyperthyroidism in our hospital from January 2006 to January 2007 were selected as research subject,and they were divided into group A （131I treatment group）30 cases and group B（antithyroid drug group）30 eases. Then the cure rate,recurrence rate , adverse reaction rate,long term complication rate and the levels of serum SACE , NO, HA , IgG, IgM, IgA, C3, CA were detected and compared. Results According the comparison, cure rate of group A was higher than that of group, the levels of serum SACE, NO, HA , IgG, IgM, IgA, C3, CA of group A were lower than those of group B, recurrence rate and adverse reaction rate of group A were lower than those of group B, but long term complication rate of group A was higher than that of group B, P 〈 0.05, there were significant differences. Conclusion The comprehensive effect of 131I in the hyperthyroidism is better, but the long term complication rate is higher, and should be paid attention to.