低分子右旋糖酐联用速尿持续静滴治疗小儿肾病综合征水肿临床观察

Low molecule dextran with continuous furosemide infusion to treat edema following children with nephrotic syndrome

目的 观察低分子右旋糖酐联用速尿持续静滴治疗小儿肾并病综合征水肿变化情况.方法 将28例小儿肾病综合征随机分为对照组（A组）和治疗组（B组）.两组均在常规治疗基础上,A组予速尿1 mg/（kg·d）静脉推注,每天一次;B组予低分子右旋糖酐10 ml/（kg·d）加速尿1 mg/（kg·d）静脉滴注,20滴/min,每天一次,观察两组患者水肿消退时间、出现多尿时间、血清白蛋白及胆固醇、24 h尿蛋白变化.结果 两组各项指标比较,差异均有统计学意义（P〈0.05）,B组显示良好疗效和安全性.结论 低分子右旋糖酐联用速尿治疗小儿肾并病综合征利尿、消肿效果好,经济实用.

Objective To observe edema variation in children with nephrotic syndrome treated with low molecule dextran and furosemide. Methods 28 children with nephrotic syndrome were divided into 2 groups randomly, control group （ GroupA ） and therapy group （GroupB）. On the basis of general therapy, patients in Group A were injeeted furosemide（ 1 mg/kg ·d）. Patients in Group B were treated with low molecule dextran （ 10 ml/kg ·d） and furosemide（ 1 mg/kg ·d） by continuous infusion. The time for edema subsidence and diuresis appearance. Serum levels of albumin and cholesterin, the variation of urine - albumen within 24 hour. Results There was distinct difference in all tl,e parameters between GroupA and GroupB （ P 〈 0.05 ）. GroupB indicated good curative effect, safety and reliability. Conclusion Low molecule dextran with furosernide have a good effect on diuresis and detumeseence. Being theraphy and cost -effeetive. They are deserved to use on a large scale clinically to treat children with nephritic syndrome.