期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

磁共振pH成像的研究 被引量：4

Magnetic resonance pH imaging
下载PDF
导出
摘要 1概述 磁共振成像（MRI）技术的重要优势在于其无放射损伤及组织结构的高分辨力,可无创实时地检测组织结构及代谢物。众所周知,人体正常机能活动有赖于正常的细胞内外环境,
作者 吴仁华 沈智威 宁立波 邱庆春
机构地区 汕头大学医学院第二附属医院放射科
出处 《国际医学放射学杂志》 2010年第5期409-410,共2页 International Journal of Medical Radiology
基金 国家自然科学基金重点项目(30930027)
关键词 磁共振成像 PH 组织结构 高分辨力 放射损伤 代谢物 外环境 细胞内
分类号 R445.2 [医药卫生—影像医学与核医学]
  • 相关文献

参考文献19

  • 1Gillies RJ,Raghunand N,Garcia-Martin ML,et al.pH imaging:a review of pH measurement methods and applications in cancers[J].IEEE Eng Med Biol Mag,2004,23:57-64.
  • 2Zhou J,Payen JF,Wilson DA,et al.Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI[J].Nat Med,2003,9:1085-1090.
  • 3Wu RH,Liu WW,Chen YW,et al.Preliminary study of mapping brain ATP and brain pH using multivoxel 31P MR spectroscopy[M] //Lim CT,Goh JCH.IFMBE Proceedings:13th International Conference on Biomedical Engineering.Berlin Heidelberg:Springer,2009:362-365.
  • 4van Sluis R,Bhujwalla ZM,Gillies RJ,et al.In vivo imaging of extracellular pH using 1H MRSI[J].Magn Reson Med,1999,41:743-750.
  • 5Alvarez -Perez J,Ballesteros P,Cerdan S.Microscopic images of intraspheroidal pH by 1H magnetic resonance chemical shift imaging of pH sensitive indicators[J].MAGMA,2005,18:293-301.
  • 6Ojugo AS,McSheehy PM,Griffiths JR,et al.Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy:a comparison of exogenous (19)F and (31)P probes[J].NMR Biomed,1999,12:495-504.
  • 7Soler -Padrós J,Pérez -Mayoral E,Domínguez L,et al.Novel generation of pH indicators for proton magnetic resonance spectroscopic imaging[J].J Med Chem,2007,50:4539-4542.
  • 8Gallagher FA,Kettunen MI,Day SE,et al.Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate[J].Nature,2008,453:940-943.
  • 9StubbsM,McSheehy PM,Griffiths JR,et al.Causes and consequences of tumour acidity and implications for treatment[J].Mol Med Today,2000,6:15-19.
  • 10Griffiths J.31P-NMR investigation of solid tumours in the living rat[J].Biosci Rep,1981,1:319-325.

二级参考文献15

  • 1J.R. Griffiths. Are cancer ceils acidic? [J]. Br. J. Cancer 1991,64:425- 427.
  • 2O.A.C.Petroff, J.W.Prichard,K.L. Behar, et al. Cerebral ntracellular pH by ^31p nuclear magnetic resonance spectroscopy [J]. Neurology.1985, 35:781- 788.
  • 3R.J. Gillies, Z. Liu, Z. Bhujwalla. 3ap-MRS measurements of extraceUular pH of tumors using 3-aminopropylphosphonate [J]. Amer. J. Physiol. 1994,267: C195-C203.
  • 4C.Gasparovic, l.Barba, J.Born, et al. A study of imidazole-based nuclear magnetic resonance probes of ceUular pH [J]. Anal Bioehem 1998,261:64-72.
  • 5P. Vermathen, A. A. Capizzano, A.A. Maudsley. Administration and 1H MRS detection of histidine in human brain: Application to In Vivo pH Measurement [J]. Magn.Reson. Med. 2000,43:665-675.
  • 6R.van Sluis, Z.M.Bhujwalla, N.Raghunand, P. Ballesteros, J. Alvarez, S. Cerdan, J.P. Galons, and R.J. Gillies. In vivo imaging of extracellular pH using ^1H MRSI [J]. Magn.Reson. Med. 1999,41:743- 750.
  • 7N.Raghunand, S.Zhang, A.D.Sherry, et al. In vivo magnetic resonance imaging of tissue pH using a novel pH-sensitive contrast agent, GdDOTA-4AmP[J]. Academic Radiology 2002,9:481-483.
  • 8N. Raghunand, C.Howison, A.D.Sherry, et al. Renal and systemic pH imaging by contrast-enhanced MRI [J]. Magn. Reson. Med. 2003,49: 249-257.
  • 9R.H.Wu, W.W.Liu, Y.W Chen, et al. Preliminary Study of Mapping Brain ATP and Brain pH Using Mttltivoxel 31p MR Spectroscopy[J].IFMBE Proceedings. 2008, 23:262-265.
  • 10K.M.Ward, R.S.Balaban. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST) [J]. Magn. Reson.Med. 2000,44:799-802.

共引文献3

同被引文献25

  • 1苗英,林伟,钱玉娥,朱碧波,任宏,韩国灿.对比增强磁化传递MRI在肺癌脑内小转移灶成像中的价值[J].中华放射学杂志,2004,38(12):1252-1255. 被引量：13
  • 2Zhibo Wen,Shuguang Hu,Fanheng Huang,Xianlong Wang,Linglang Guo,Xianyue Quan,Silun Wang,Jinyuan Zhou.MR imaging of high-grade brain tumors using endogenous protein and peptide-based contrast[J].Neuroimage.2010(2)
  • 3Dieta Brandsma,Lukas Stalpers,Walter Taal,Peter Sminia,Martin J van den Bent.Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas[J].Lancet Oncology.2008(5)
  • 4Jinyuan Zhou,Peter C.M. van Zijl.Chemical exchange saturation transfer imaging and spectroscopy[J].Progress in Nuclear Magnetic Resonance Spectroscopy.2006(2)
  • 5S.J. Price,N.G. Burnet,T. Donovan,H.A.L. Green,A. Pe?a,N.M. Antoun,J.D. Pickard,T.A. Carpenter,J.H. Gillard.Diffusion Tensor Imaging of Brain Tumours at 3<ce:hsp sp="0.25"/>T: A Potential Tool for Assessing White Matter Tract Invasion?[J].Clinical Radiology.2003(6)
  • 6V. Guivel-Scharen,T. Sinnwell,S.D. Wolff,R.S. Balaban.Detection of Proton Chemical Exchange between Metabolites and Water in Biological Tissues[J].Journal of Magnetic Resonance.1998(1)
  • 7N. M. deSouza,J. V. Hajnal,C. J. Baudouin.Potential for increasing conspicuity of short-T1 lesions in the brain using magnetisation transfer imaging[J].Neuroradiology.1995(4)
  • 8张小玲,黄明刚,雷晓燕,张艳,齐敏.不典型脑膜瘤的MR表现[J].实用放射学杂志,2008,24(7):880-882. 被引量：12
  • 9张体江,龚启勇.磁化传递成像及其在精神疾病中的研究现状[J].磁共振成像,2010,1(6):468-472. 被引量：5
  • 10宁立波,邱庆春,肖叶玉,吴仁华.化学交换饱和转移在MRpH成像方面的应用[J].中华放射学杂志,2011,45(4):414-416. 被引量：5

引证文献4

二级引证文献20

国际医学放射学杂志
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部