硝苯地平缓释片与硝苯地平控释片治疗高血压的疗效比较

Comparison of the effect of nifedipine sustained-release tablet and nifedipine controlled-release tablet in hypertension

目的比较硝苯地平缓释片与硝苯地平控释片治疗高血压病的临床疗效。方法 112例高血压患者随机分为控释片组和缓释片组,各61例。缓释片组服用硝苯地平缓释片10mg,每天2次;控释片组服用硝苯地平控释片30mg,每天1次。2组均治疗8周。观察2组血压变化情况、谷/峰(T/P)比值和不良反应发生情况。结果控释片组总有效率为91.8%高于缓释片组的80.3%(P<0.05);2组治疗后血压均降低,控释片组HR降低,缓释片组HR升高,与治疗后比较差异有统计学意义(P<0.05);控释片组治疗后血压、心率均低于缓释片组(P<0.05);控释片组SBP与DBP降压T/P值分别为92.1%与85.9%,缓释片组分别为29.7%与25.6%;控释片组不良反应发生率低于缓释片组(P<0.05)。结论硝苯地平控释片具有良好的抗高血压作用,不良反应少,效果优于硝苯地平缓释片。

Objective To compare clinical effect of nifedipine sustained-release tablet（SR）and nifedipine controlled-release tablet（GITS）in hypertension.Methods 112 cases of hypertension patients were randomly divided into GITS group and SR group,61 cases of each.SR group was given nifedipine SR 10mg,two times a day;GITS group was given nifedipine 30mg,once per day.Two groups were treated for 8 weeks.Observed blood pressure changes,trough/peak（T/P）ratio and adverse reaction.Results The total effective rate of GITS group（91.8%）was higher than that in SR group（80.3%）（P0.05）;After treatment,blood pressure of two groups all decreased,heart rate（HR）of GITS group decreased,SR group increased,compared with after treatment,there was significant difference（P0.05）.Blood pressure and HR of GITS group were lower than that in SR group（P0.05）;SBP and DBP buck T/P ratio of GITS groups were 92.1% and 85.9%,SR group were 29.7% and 25.6%;Adverse reaction rate of GITS group was lower than SR group（P0.05）.Conclusion Nifedipine GITS has a good antihypertensive effect,less adverse reaction and more effective than nifedipine SR.