宫颈癌中Eag1钾离子通道的表达以及缺氧对其的调控作用
摘要
目的研究不同病变宫颈组织中Eag1以及宫颈癌Hela细胞膜上Eag1钾离子通道表达的情况。方法采用免疫组化、免疫荧光法，检测不同宫颈组织（慢性宫颈炎组20例，宫颈上皮内瘤变组40例）和宫颈癌（宫颈鳞癌组80例）Hela细胞中Eagl蛋白的表达。结果宫颈上皮内瘤变组Eagl蛋白的表达[32．50％（13／40）]明显高于慢性宫颈炎组[5．00％（1／20）]（P〈0．01），宫颈癌组Eag1的表达[65．00％（52／80）]明显高于宫颈上皮内瘤变组（32．50％）；Eagl的表达随临床分期的增高而增加；与病理分级无明显相关性。正常培养的宫颈癌Hela细胞中即有Eag1表达。结论Eag1钾离子通道蛋白在宫颈癌发生、发展中起重要的作用，其水平升高可能导致肿瘤向恶性表型发展。
出处
《中国综合临床》
2010年第9期994-996,共3页
Clinical Medicine of China
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