意大利蜂工蜂幼虫和蛹的药理作用初探

Study on pharmacologic action of worker bee larvae and pupae of Italian Bee(Apis mellifera ligustica)

从抗肿瘤、抗衰老、调节机体免疫功能三方面对工蜂幼虫、蛹的药理作用进行了研究，结果表 明，工蜂幼虫、蛹对小鼠Ｓ１８０肿瘤生长有明显的抑制作用，其抑瘤率分别达６０．９２％和６４．３７％，荷瘤小鼠的生命延长率分别达８０． ６５％和８１． ７４％；工蜂幼虫、蛹能提高大鼠脑、肝脏和血液中ＳＯＤ的活性，降低ＭＤＡ的含量，提高小鼠脑组织中ＲＮＡ和蛋白质的含量；工蜂幼虫、蛹能提高小鼠Ｔ淋巴细胞转化功能、碳廓清指数和胸腺指数，具有提高机体的细胞免疫和非特异性免疫功能的作用，工蜂幼虫、蛹的药理作用与蜂王幼虫相比，差异不显著。

Study on pharmacologic action of worker bee larvae and pupae of Italian Bee (Apis mellifera ligustica was carried out in 3 aspects :antitumor , antiagting , regulation of immunity function. The results showed that the worker bee larvae and pupae had evident inhibitive effect on S180 tumor growth. The in- hibiting tumor rates were 60. 92% and 64. 37% respectively, and the prolonging longetive rates were 80. 65 % and 81. 74 % respectively ; The worker bee larvae and pupae sigiuficantly increased the SOD activi- ties and reduce the contents of MDA of brain, liver and blood of rats, while significantly increased RNA and protein contents in brain tissue of mice ;The worker bee larvae and pupae can significantly increase T- lymphocyte transformation function , charcoal clearance index and thymus index , and had obvious effect of cell-mediated immunity and unspeific immunity. No significant difference existed between worker bee lar- vae , pupae and queen bee larvae.