骨炎定方治疗肝肾不足气虚血瘀型膝骨关节炎54例疗效观察

Therapeutic Effect of Guyangding Prescription on Knee Osteoarthritis with Liver-kidney Insufficiency and Qi Deficiency and Blood Stasis

【目的】观察和评价骨炎定方治疗肝肾不足气虚血瘀型膝骨关节炎(OA)患者的临床疗效。【方法】将106例膝OA患者随机分为治疗组54例和对照组52例。治疗组服用骨炎定方(由黄芪、红花、骨碎补、补骨脂、木瓜、牛膝等药物组成),对照组服用塞来昔布。2组均以4周为1个疗程,治疗3个疗程后进行疗效比较,并评价其安全性。【结果】总有效率治疗组为94.44%,对照组为82.70%,2组比较差异有显著性意义(P<0.05),且2组在观察期间各项实验室检测指标均基本正常,未出现不良反应。【结论】骨炎定方能有效改善肝肾不足、气虚血瘀型膝OA患者的临床症状,疗效优于塞来昔布,并可有效地缓解膝关节疼痛,改善膝关节功能,药物安全性好,无明显毒副作用。

Objective To observe the therapeutic effect of Guyangding Prescription （GP） on knee osteoarthritis（OA） with liver-kidney insufficiency and Qi deficiency and blood stasis. Methods One hundred and six qualified patients were randomized into two groups： 54 in the treatment group received GP （mainly composed of Radix Astragali , Flos Carthami, Rhizoma Drynariae, Fructus Psoraleae, Fructus Chaenomelis, Radix Achyranthis Bidentatae, etc. ）, and 52 in the control group received celecoxib. Four weeks constituted one treatment course, and the therapeutic effect and the safety were evaluated after 12 weeks. Results After treatment, the total effective rate was 94.44% in the treatment group, and 82.70% in the control group, and the difference was significant （P 〈 0. 05）, indicating that the therapeutic effect of GP was superior to that of celecoxib. During the treatment, no adverse effect was found. Conclusion GP is effective on relieving pain in the knee joint and improving knee function of knee OA patients with liver-kidney insufficiency and Qi deficiency and blood stasis. Its effect is better than celecoxib, without toxic or side effects.