温阳益气汤对急性冠状动脉综合征患者炎症反应及免疫功能的影响

Effect of Yang-warming and Qi-strengthening Decoction on Inflammatory Reaction and Immune Function of Acute Coronary Syndrome Patients

【目的】观察温阳益气汤对急性冠状动脉综合征(ACS)患者炎症反应及免疫功能的影响。【方法】将106例ACS患者随机分为治疗组(55例)和对照组(51例),2组均给予常规治疗,治疗组加用温阳益气汤(由巴戟天、黄芪、丹参、淫羊藿、麦冬、熟附子、三七、水蛭等组成),疗程均为14d。观察治疗前后T淋巴细胞亚群(CD3+、CD3+CD4+、CD3+CD8+)、高敏C-反应蛋白(Hs-CRP)、N-末端原脑利钠肽(NT-Pro BNP)等指标的变化。【结果】治疗后2组CD3+、CD3+CD4+、CD3+CD8+、Hs-CRP、NT-ProBNP均有不同程度的改善(与治疗前比较,P<0.05或P<0.01)。2组治疗后各项指标比较,差异也有显著性意义(P<0.05或P<0.01)。【结论】温阳益气汤有助于调节ACS患者的细胞免疫功能并控制炎症,减少感染并发症,改善心功能,提示免疫调节及控制炎症可能是治疗ACS的另一新途径。

Objective To observe the effect of Yang-warming and Qi-strengthening Decoction （YQD） on inflammatory reaction and immune function of acute coronary syndrome （ACS） patients. Methods One hundred and six ACS patients were randomized into treatment group （N = 55 ） and control group （N = 51 ）. The two groups were given routine treatment, and the treatment group additionally received YQD （mainly composed of Radix Morindae Officinalis, Radix Salviae Miltiorrhizae, Radix Astragali, Herba Epimedii, Radix Ophiopogonis, Radix Aconiti Lateralis Preparata, Radix Notoginseng, Hirudo, etc. ）. The treatment lasted 14 days. The percentages of T lymphocyte subtypes （ CD3 ^＋ , CD3^ ＋ CD4^ ＋ , CD3 ^＋ CD8 ^＋ ）, hypersensitive C-reactive protein （ Hs-CRP）, and N-terminal pro-brain natriuretic peptide （NT-ProBNP） were observed before and after treatment. Results After treatment, the percentages of T lymphocyte subtypes （CD3^ ＋ , CD3 ^＋ CD4^ ＋ , CD3^ ＋ CD8^ ＋ ）, Hs-CRP, and NT- ProBNP were improved in the two groups to some extend （P 〈 0.05 or P 〈 0.01 compared with those before treatment）, and the differences were significant between the two groups （P 〈 0.05 or P 〈 0.01 ）. Conclusion YQD can regulate the cellular immune function, relieve inflammation, reduce incidence of infection complications and improve cardiac function of ACS patients, indicating that immunoregulation and relieving inflammation may be a new therapeutic method for ACS.