摘要
本文用原子吸收分光光度法测定了大鼠分别服用苯妥英锌和苯妥英钠13周后(每天剂量为12mg/kg体重),肝脏、全脑、齿龈和血清锌铜的含量。苯妥英锌使齿龈和肝脏锌分别增高80％和49％,全脑和血清锌分别降低39％和35％,而苯妥英钠使齿龈和肝脏锌分别降低70％和28％,血清锌增高41％。两药均使全脑和齿龈铜降低。
The concentrations of Zn^(++) and Cu^(++) were determined by atomic absorption sepectrophotometry in the liver, train, gum and sefum of rats treated with administration of phenytoin zinc (Ⅱ) and phenytoin sodium (Ⅰ) at doses of 12 mg/( kg·d) respectively for 13 wk. The Zn^(++) increases with 80% and 41% were found in the gum and liver respectively as well as the Zn^(++) decreases with 39% and 35% in the brain and serum of rats treated with Ⅱ respectively, while the Zn^(++) decreases with 70% and 23% were found in the gum and liver respectively as well as the increase of 41% of serum Zn^(++) treated with 1. The Cu^(++) levels deereases in the brain and gum might result from treatment I and II.
关键词
苯妥英锌
苯妥英钠
光度法
Phenytoin zinc
Phenytoin sodium atomic absorption spectrophotometry
