钌配合物[Ru(phen)_2(7-R-dppz)]^(2+)(R=-CH_3,-F,-CF_3)的合成、表征及DNA键合性质(英文)

Synthesis,characterization,DNA-binding of complexes [Ru(phen)_2(7-R-dppz)]^(2+)(R =-CH_3,-F,-CF_3)

合成并表征了三个钌(II)多吡啶配合物[Ru(phen)2(7-CH3-dppz)]2+(i)、[Ru(phen)2(7-F-dppz)]2+(ii)和[Ru(phen)2(7-CF3-dppz)]2+(iii).利用光谱法和粘度实验研究了配合物与DNA的结合行为.结果表明3个配合物均以插入方式与DNA结合,其与DNA的亲和力顺序为(ii)>(i)>(iii).同时采用密度泛函(DFT)理论计算合理解释了3个配合物与DNA结合行为的差异.

Three Ru（Ⅱ） polypyridyl complexes, [Ru（pben）2（7-CH3-dppz）]2＋ （i）, [Ru（phen）2（7-F-dppz）]2＋ （ii） and [Ru（phen）2（7-CF3-dppz）]2＋ （iii） have been synthesized and characterized by elemental analysis, ES-MS （electrospray mass spectra）, IHNMR. The DNA-binding behaviors of these complexes have been studied by spectroscopic methods and viscosity measurements. The results indicate that the three complexes all bind to CT-DNA （calf thymus DNA） in an intercalative mode, and the DNA-binding affinity follows the order of （ii） 〉 （i） 〉 （iii）. Theoretical studies for these complexes have been also carried out with the density functional theory （DFT） method. The difference in the DNA-binding behaviors of three complexes can be reasonably explained by the DFT calculations.