国产头孢替唑钠用于临床急性呼吸道及泌尿道感染治疗的疗效观察

Therapeutic effects of domestic ceftezole sodium in the treatment of acute respiratory tract and urinary tract infection

目的评价国产头孢替唑钠用于急性呼吸道及泌尿道感染治疗的有效性及安全性。方法以进口注射用头孢替唑钠(特子社复)为对照,136例急性呼吸道及泌尿道感染患者随机分为观察组(n=70)和对照组(n=66),分别接受国产和进口注射用头孢替唑钠治疗,疗程均为7～14d。以临床有效率和细菌清除率评价药物疗效,以不良反应发生率评价其安全性。结果观察组和对照组临床有效率和细菌清除率分别为94.3%对92.5%,89.7%对87.0%;不良反应发生率分别为5.7%对6.1%,组间相比差异均无统计学意义(P>0.05)。结论国产头孢替唑钠用于急性呼吸道及泌尿道感染疗效及安全性与进口头孢替唑钠相当。

Objective To evaluate the efficacy and safety of domestic ceftezole sodium in the treatment of acute respiratory tract infection and urinary tract infection. Methods： Totally 136 patients with acute respiratory tract infection and urinary tract infection were randomly divided into observation group （n=70）and control group （n=66）which were administered with domestic and imported ceftezole sodium respectively for 7-14 days. The efficacy was evaluated by the clinical effective rate and bacteria eradication rate, and the safety was evaluated by the rate of adverse reactions. Results： The clinical effective rates and bacteria eradication rates of observation group and control group were 95.7% vs 92.4% and 89.7% vs 87.0% respectively （P〉0.05）. The rates of adverse reactions of two groups were 5.7% vs 6.1% （P〉0.05）. Conclusion： Domestic ceftezole sodium seems to be as effective and safe as imported ceftezole sodium in the treatment of acute respiratory tract infection and urinary tract infection.