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雷莫拉宁抗菌机制的研究进展 被引量：1

Research progress of antimicrobial mechanisms of ramoplanin
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摘要 一直以来,新型抗生素雷莫拉宁的抗菌作用机制存在争议。近期研究表明,雷莫拉宁主要通过结合转糖基酶的作用底物LipidⅡ,使细菌细胞壁合成受阻并致细胞凋亡。本文主要综述其抗菌机制的研究进展。 Antimicrobial mechanisms of new antibiotics ramoplanin have been argued for a long time. But recent studies have shown that ramoplanin can obstruct the synthesis of cell wall and cause apoptosis by combining with Lipid Ⅱ. This review describes the research progress of antimicrobial mechanisms of ramoplanin.
作者 尹培军 李继安 陈代杰
机构地区 上海师范大学生命与环境科学学院生物系 上海医药工业研究院创新药物与制药工艺国家重点实验室
出处 《世界临床药物》 CAS 2010年第9期554-557,共4页 World Clinical Drug
基金 国家科技支撑计划(2005DKA21203)
关键词 雷莫拉宁 抗菌机制 肽聚糖 LIPID Ⅱ ramoplanin antimicrobial mechanism peptidoglycan Lipid Ⅱ
分类号 R978.16 [医药卫生—药品] R962 [医药卫生—药理学]
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参考文献23

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世界临床药物
2010年 第9期

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