脑卒中恢复期血液微量元素和抗氧化酶含量的变化

Observation on Changes of Blood Trace Elements & Antioxidase in Convalescent Cerebral Apoplexy

对９１例脑卒中恢复期患者就血清微量元素Ｃｕ２＋、Ｆｅ２＋、Ｚｎ２＋、Ｚｎ２＋／Ｃｕ２＋和血浆丙二醛（ＭＤＡ），超氧化物歧化酶（ＳＯＤ），过氧化氢酶（ＣＡＴ），谷胱甘肽过氧化酶（ＧＳＨ）含量做了检测和观察：脑卒中恢复期患者血浆ＭＤＡ含量明显升高（Ｐ＜０．０１）；ＳＯＤ变化与ＭＤＡ含量呈负相关；脑梗塞病人血清微量元素铁含量明显升高（Ｐ＜０．０１），ＧＳＨ变化与硒含量呈正相关（Ｐ＜０．０５）。表明：脑卒中恢复期病人存在某些微量元素及脂质过氧化的紊乱，参与脑卒中的发生。

In 91 cases of convalescent cerebral apoplexy,the serum trace elements such as Cu 2+ ,Fe 2+ ,Zn 2+ and Zn 2+ /Cu 2+ ,malonyldial dehyde(MDA),superoxide dismuta(SOD),catalase(CAT) and glutathione superoxydase(GSH) were tested.The result showed that the content of MDA obviously rised which was negatively correlated to that of SOD. In cerebral infarction,the content of Fe 2+ obviously rised and the change of GSH was positively correlated to the content of Se. It indicates that there is the disturbance of the trace elements and antioxidase in convalescent cerebral apoplexy which exists in the whole process of the disease.